Magali Hennion

TL;DR: It is found that histone modifications predominantly changed during memory acquisition and correlated surprisingly little with changes in gene expression, providing evidence for a molecular framework ofMemory acquisition and maintenance, wherein DNA methylation could alter the expression and splicing of genes involved in functional plasticity and synaptic wiring.

TL;DR: The transcriptome-wide effects of the proteasome inhibitor bortezomib on estrogen-regulated transcription in MCF7 human breast cancer cells were investigated and it was found that H2Bub1 levels decrease during tumor progression, supporting a tumor suppressor role for H2bub1 in breast cancer.

TL;DR: It is shown that histone H2B monoubiquitination (H2Bub1) significantly increases during differentiation of human mesenchymal stem cells (hMSCs) and various lineage-committed precursor cells and in diverse organisms.

TL;DR: Mechanistically, cross-species genomic analyses and complete ciliary rescue of knockout MCCs identify TAp73 as the conserved central transcriptional integrator of multiciliogenesis.

TL;DR: The findings provide novel and compelling insight into the mechanisms associated with aSyn neurotoxicity in dopaminergic cells, which could be ameliorated with an HDACi.