S
Sushrut S. Waikar
Researcher at Boston University
Publications - 288
Citations - 16295
Sushrut S. Waikar is an academic researcher from Boston University. The author has contributed to research in topics: Kidney disease & Acute kidney injury. The author has an hindex of 56, co-authored 244 publications receiving 12435 citations. Previous affiliations of Sushrut S. Waikar include Brigham and Women's Hospital & Washington University in St. Louis.
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Journal ArticleDOI
Single cell transcriptional and chromatin accessibility profiling redefine cellular heterogeneity in the adult human kidney.
Yoshiharu Muto,Parker C. Wilson,Nicolas Ledru,Haojia Wu,Henrik Dimke,Henrik Dimke,Sushrut S. Waikar,Benjamin D. Humphreys +7 more
TL;DR: In this paper, the authors performed single nucleus ATAC (snATAC-seq) and RNA (snRNAseq) sequencing to generate paired, cell-type-specific chromatin accessibility and transcriptional profiles of the adult human kidney.
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Plasma FGF23 levels increase rapidly after acute kidney injury
Marta Christov,Marta Christov,Sushrut S. Waikar,Renata C. Pereira,Andrea Havasi,David E. Leaf,David Goltzman,Paola Divieti Pajevic,Myles Wolf,Harald Jüppner +9 more
TL;DR: In this paper, the authors used a murine folic acid-induced nephropathy model and found that plasma FGF23 levels increased significantly from baseline already after 1h of acute kidney injury (AKI), with an 18-fold increase at 24h.
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Mortality Associated with Low Serum Sodium Concentration in Maintenance Hemodialysis
TL;DR: In this paper, the authors examined the association between predialysis serum sodium concentration and mortality in patients undergoing hemodialysis for end-stage renal disease, a condition in which arginine vasopressin does not affect water excretion and osmoregulation.
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Detection of renal cell carcinoma using plasma and urine cell-free DNA methylomes.
Pier Vitale Nuzzo,Pier Vitale Nuzzo,Jacob E. Berchuck,Keegan Korthauer,Sándor Spisák,Amin Nassar,Sarah Abou Alaiwi,Ankur Chakravarthy,Shu Yi Shen,Ziad Bakouny,Francesco Boccardo,John A. Steinharter,Gabrielle Bouchard,Catherine Curran,Wenting Pan,Sylvan C. Baca,Sylvan C. Baca,Ji-Heui Seo,Gwo-Shu Mary Lee,M. Dror Michaelson,Steven L. Chang,Sushrut S. Waikar,Sushrut S. Waikar,Guru Sonpavde,Rafael A. Irizarry,Mark Pomerantz,Daniel D. De Carvalho,Daniel D. De Carvalho,Toni K. Choueiri,Toni K. Choueiri,Matthew L. Freedman,Matthew L. Freedman +31 more
TL;DR: A cell-free DNA-methylation sequencing assay accurately identifies renal cell carcinoma using plasma and urine samples.
Journal ArticleDOI
Pharmacological GLI2 inhibition prevents myofibroblast cell-cycle progression and reduces kidney fibrosis
Rafael Kramann,Susanne V. Fleig,Rebekka K. Schneider,Steven L. Fabian,Derek P. DiRocco,Omar H. Maarouf,Janewit Wongboonsin,Yoichiro Ikeda,Dirk Heckl,Steven L. Chang,Helmut G. Rennke,Sushrut S. Waikar,Benjamin D. Humphreys +12 more
TL;DR: It is demonstrated that GLI2, but not GLI1, drives myofibroblast cell-cycle progression in cultured mesenchymal stem cell-like progenitors, and pharmacologic targeting of this pathway with darinaparsin reduced fibrosis through reduction ofGLI2 protein levels and subsequent cell- cycle arrest in myofIBroblasts.