D
David E. Leaf
Researcher at Brigham and Women's Hospital
Publications - 145
Citations - 8486
David E. Leaf is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Acute kidney injury & Medicine. The author has an hindex of 37, co-authored 127 publications receiving 5347 citations. Previous affiliations of David E. Leaf include Harvard University & University of California, Los Angeles.
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Journal ArticleDOI
COVID-19 and coagulation: bleeding and thrombotic manifestations of SARS-CoV-2 infection.
Hanny Al-Samkari,Rebecca Karp Leaf,Walter H. Dzik,Jonathan C. T. Carlson,Annemarie E. Fogerty,Anem Waheed,Katayoon Goodarzi,Pavan K. Bendapudi,Larissa Bornikova,Shruti Gupta,Shruti Gupta,David E. Leaf,David E. Leaf,David J. Kuter,Rachel P. Rosovsky +14 more
TL;DR: Elevated D-dimer at initial presentation was predictive of coagulation-associated complications during hospitalization and ESR, CRP, fibrinogen, ferritin, and procalcitonin were higher in patients with thrombotic complications than in those without.
Journal ArticleDOI
Factors Associated With Death in Critically Ill Patients With Coronavirus Disease 2019 in the US
Shruti Gupta,Salim S. Hayek,Wei Wang,Lili Chan,Kusum S. Mathews,Michal L. Melamed,Samantha K. Brenner,Amanda K. Leonberg-Yoo,Edward J. Schenck,Jared Radbel,Jochen Reiser,Anip Bansal,Anand Srivastava,Yan Zhou,Anne Sutherland,Adam E. Green,Alexandre M. Shehata,Nitender Goyal,Anitha Vijayan,Juan Carlos Q. Velez,Juan Carlos Q. Velez,Shahzad Shaefi,Chirag R. Parikh,Justin Arunthamakun,Ambarish M. Athavale,Allon N. Friedman,Samuel A.P. Short,Zoe A. Kibbelaar,Samah Abu Omar,Andrew J Admon,John P. Donnelly,Hayley B. Gershengorn,Hayley B. Gershengorn,Miguel A. Hernán,Miguel A. Hernán,Matthew W. Semler,David E. Leaf +36 more
TL;DR: This study identified demographic, clinical, and hospital-level risk factors that may be associated with death in critically ill patients with COVID-19 and can facilitate the identification of medications and supportive therapies to improve outcomes.
Journal ArticleDOI
Clinicopathological features of acute kidney injury associated with immune checkpoint inhibitors
Frank B. Cortazar,Kristen A. Marrone,Megan L. Troxell,Kenneth M. Ralto,Melanie P. Hoenig,Julie R. Brahmer,Dung T. Le,Evan J. Lipson,Ilya G. Glezerman,Jedd D. Wolchok,Lynn D. Cornell,Paul Feldman,Michael B. Stokes,Sarah A. Zapata,F. Stephen Hodi,Patrick A. Ott,Michifumi Yamashita,David E. Leaf +17 more
TL;DR: CPI-induced AKI is a new entity that presents with clinical and histologic features similar to other causes of drug-induced acute tubulointerstitial nephritis, though with a longer latency period, and glucocorticoids appear to be a potentially effective treatment strategy.
Journal ArticleDOI
Association Between Early Treatment With Tocilizumab and Mortality Among Critically Ill Patients With COVID-19.
Shruti Gupta,Wei Wang,Salim S. Hayek,Lili Chan,Kusum S. Mathews,Michal L. Melamed,Samantha K. Brenner,Samantha K. Brenner,Amanda K. Leonberg-Yoo,Edward J. Schenck,Jared Radbel,Jochen Reiser,Anip Bansal,Anand Srivastava,Yan Zhou,Diana Finkel,Adam E. Green,Mary Mallappallil,Anthony J. Faugno,Jingjing Zhang,Juan Carlos Q. Velez,Juan Carlos Q. Velez,Shahzad Shaefi,Chirag R. Parikh,David M. Charytan,Ambarish M. Athavale,Allon N. Friedman,Roberta E. Redfern,Samuel A.P. Short,Simon Correa,Kapil K. Pokharel,Andrew J Admon,John P. Donnelly,Hayley B. Gershengorn,Hayley B. Gershengorn,David J. Douin,Matthew W. Semler,Miguel A. Hernán,David E. Leaf +38 more
TL;DR: Among critically ill patients with COVID-19 in this cohort study, the risk of in-hospital mortality in this study was lower in patients treated with tocilizumab in the first 2 days of ICU admission compared with patients whose treatment did not include early use of tocilzumab, and the findings may be susceptible to unmeasured confounding.
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HIV infection and the risk of diabetes mellitus.
Adeel A. Butt,Kathleen A. McGinnis,Maria C. Rodriguez-Barradas,Stephen Crystal,Michael S. Simberkoff,Matthew Bidwell Goetz,David E. Leaf,Amy C. Justice +7 more
TL;DR: Although HIV infection itself is not associated with increased risk ofabetes, increasing age; HCV coinfection and BMI have a more profound effect upon the risk of diabetes among HIV-infected persons, and long-term ARV treatment also increases risk.