Suzana Aulic

TL;DR: In vitro data revealed that the presence of PrPC fosters the higher uptake of α-Syn amyloid fibrils, which was also confirmed in vivo in wild type (Prnp+/+) compared to PrP knock-out mice, indicating a link between the two proteins.

TL;DR: Using α- Synuclein short amyloid fibrils as seed, endogenous α-syn aggregates and accumulates over several passages in cell culture, providing an excellent tool for potential therapeutic screening of pathogenic α- synuclein aggregates.

TL;DR: These results could be used to estimate the binding affinity of the viral protein to different allelic variants of ACE2 receptors discovered in COVID-19 patients and for the effective structure-based design and development of neutralizing antibodies, vaccines, and protein/protein inhibitors against this terrible new coronavirus.

TL;DR: An overview of the main DNA repair pathways, with special focus on the role played by homologous repair and the RAD51 recombinase protein in the cellular DNA damage response, and a survey of the most promising therapeutic strategies aimed at targeting RAD51 in experimental oncology.

TL;DR: The salient traits of these small molecules that are able to detect and modulate aggregated forms of several proteins involved in protein misfolding diseases are reviewed.