Svetlana V. Komarova

TL;DR: It is shown that the cytokine RANKL (receptor activator of NF-κB ligand) triggers migration of human epithelial cancer cells and melanoma cells that express the receptor RANK.

TL;DR: The mathematical model revealed that interactions among osteoblasts and osteoclasts result in complex, nonlinear system behavior, which cannot be deduced from studies of each cell type alone, and will be useful in future studies assessing the impact of cytokines, growth factors, and potential therapies on the overall process of remodeling in normal bone.

TL;DR: Progressive differentiation coincided with changes in cellular metabolism and mitochondrial activity, which are likely to play key roles in osteoblast function.

TL;DR: It is shown that certain magnesium phosphate phases such as newberyite and cattiite are able to promote in vivo osteogenic activity in a similar way to calcium phosphates such as hydroxyapatite and brushite, which confirms the great potential of magnesium phosphate ceramics in the development of new biomaterials for bone regeneration.

TL;DR: Investigation of the effect of acidosis on the osteoclastogenic transcription factor NFATc1 revealed high levels of expression of ovarian cancer G protein-coupled receptor 1, which links extracellular acidification to elevation of [Ca2+]i.