Journal ArticleDOI
Mathematical model predicts a critical role for osteoclast autocrine regulation in the control of bone remodeling
Reads0
Chats0
TLDR
The mathematical model revealed that interactions among osteoblasts and osteoclasts result in complex, nonlinear system behavior, which cannot be deduced from studies of each cell type alone, and will be useful in future studies assessing the impact of cytokines, growth factors, and potential therapies on the overall process of remodeling in normal bone.About:
This article is published in Bone.The article was published on 2003-08-01. It has received 264 citations till now. The article focuses on the topics: Bone remodeling period & Bone remodeling.read more
Citations
More filters
Journal ArticleDOI
Modeling the interactions between osteoblast and osteoclast activities in bone remodeling
TL;DR: A mathematical model explaining the interactions between osteoblasts and osteoclasts, two cell types specialized in the maintenance of the bone integrity, predicts that combinations of anti-resorptive and anabolic therapies provide significant benefits compared with monotherapy, especially for certain type of skeletal disease.
Journal ArticleDOI
Model structure and control of bone remodeling: a theoretical study.
Peter Pivonka,Jan Zimak,David Smith,Bruce S. Gardiner,Colin R. Dunstan,Natalie A. Sims,T. John Martin,Gregory R. Mundy +7 more
TL;DR: An extended bone-cell dynamics model describing functional behaviour of basic multicellular units (BMUs) responsible for bone resorption and formation is formulated and it is found that there is a preferred arrangement for ligand expression on particular cell types, and that this arrangement coincides with biological observations.
Journal ArticleDOI
A bone remodelling model coupling microdamage growth and repair by 3D BMU-activity
TL;DR: A bone remodelling continuous model able to simulate microdamage growth and repair in a coupled way and able therefore to predict the occurrence of “stress fractures” is proposed.
Journal ArticleDOI
Bone morphogenic protein 2 directly enhances differentiation of murine osteoclast precursors.
Eric D. Jensen,Lan Pham,Charles J. Billington,Kelly Espe,Ann E. Carlson,Jennifer J. Westendorf,Anna Petryk,Rajaram Gopalakrishnan,Kim C. Mansky +8 more
TL;DR: It is found that BMP2 synergizes with suboptimal levels of receptor activator of NF‐κB ligand (RANKL) to enhance in vitro differentiation of osteoclast‐like cells, and that autocrine BMP signaling directly promotes the differentiation of bone marrow‐derived cells.
References
More filters
Journal ArticleDOI
Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL
Hisataka Yasuda,Nobuyuki Shima,Nobuaki Nakagawa,Kyoji Yamaguchi,Masahiko Kinosaki,Shin Ichi Mochizuki,Akihiro Tomoyasu,Kazuki Yano,Masaaki Goto,Akihiko Murakami,Eisuke Tsuda,Tomonori Morinaga,Kanji Higashio,Nobuyuki Udagawa,Naoyuki Takahashi,Tatsuo Suda +15 more
TL;DR: In this article, a membrane-bound osteoclast differentiation factor (ODF) was found to induce OCL formation from osteoblasts/stromal cells in the presence of bone-resorbing factors.
Journal ArticleDOI
Osteonal and hemi-osteonal remodeling: the spatial and temporal framework for signal traffic in adult human bone.
TL;DR: The bone replacement process in the adult skeleton is known as remodeling, and when bone is removed by osteoclasts, new bone is laid down by osteoblasts in the same place, because the load bearing requirement is unchanged.
Journal ArticleDOI
Skeletal structural adaptations to mechanical usage (SATMU): 1. Redefining Wolff's law: the bone modeling problem.
TL;DR: The theory correctly predicts each of the 6 known "principal adaptations" of lamellar bone, which provide a critical test of any such theory for this organ.
Osteoclast differentiation factor is a ligand for osteoprotegerin/ osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL. Proc Natl Acad Sci USA 95: 3597-602
H. Yasuda,Nobuyuki Shima,N. Nakagawa,K. Yamaguchi,Masahiko Kinosaki,Shin Ichi Mochizuki,A. Tomoyasu,Kazuki Yano,M. Goto,A. Murakami,Eisuke Tsuda,T. Morinaga,K. Higashio,N. Udagawa,N. Takahashi,T. Suda +15 more
TL;DR: A genetically engineered soluble form containing the extracellular domain of the protein induced OCL formation from spleen cells in the absence of osteoblasts/stromal cells, and it was concluded that the membrane-bound protein is osteoclast differentiation factor (ODF), a long-sought ligand mediating an essential signal to osteOClast progenitors for their differentiation into osteoclasts.