Swee Lay Thein

TL;DR: Airway NO flux was not elevated in the SCD children nor correlated with airways obstruction, suggesting that airway obstruction, at least in someSCD children, is not due to asthma.

TL;DR: A high-resolution bacterial clone contig spanning 3 Mb covering this critical region of approximately 4 Mb between the markers D6S408 and D 6S292 on chromosome 6q23 is described.

TL;DR: The approach to managing adults with SCD needs to reevaluate by putting a greater emphasis on multidisciplinary care while proactively considering curative options (hematopoietic stem cell transplant and gene therapy) and experimental pharmacological agents for adults withSCD of all ages before complications render the patients ineligible for these treatments.

TL;DR: The incidence of VTE in the patient cohort was higher than in the non-SCD black population; patients of all SCD genotypes with VTE had significantly elevated steady-state platelet counts compared to those without; and consideration of longer VTE prophylaxis for acute hospital admissions in SCD is suggested.

TL;DR: Platelet aggregation and in vitro thrombus formation were upregulated in SCD mice and were inhibited when mice were subjected to pharmacological inhibition of NLRP3 and BTK.