S
Swee Lay Thein
Researcher at National Institutes of Health
Publications - 335
Citations - 21617
Swee Lay Thein is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Fetal hemoglobin & Population. The author has an hindex of 62, co-authored 316 publications receiving 19670 citations. Previous affiliations of Swee Lay Thein include King's College & University of Oxford.
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Mitapivat increases ATP and decreases oxidative stress and erythrocyte mitochondria retention in a SCD mouse model.
Zenaide M.N. Quezado,Sayuri Kamimura,Meghann Smith,Xunde Wang,Michael R. Heaven,Sirsendu Jana,Sebastian Vogel,Patricia M. Zerfas,Christian A. Combs,Luis E.F. Almeida,Quan Li,Martha Quezado,Iren Horkayne-Szakaly,Penelope A. Kosinski,Shaoxia Yu,Unnati Kapadnis,Charles Kung,Lenny Dang,Paul Wakim,William A. Eaton,Abdu I. Alayash,Swee Lay Thein +21 more
TL;DR: In this article , mitapivat was used to activate erythrocyte pyruvate kinase (PKR) and improve sickling kinetics in mice with SCD.
Journal ArticleDOI
Two novel (R(-11)C; T394D) and two repeat missense mutations in the protein C gene associated with venous thrombosis in six kindreds.
Helen Ireland,M Boisclair,Julia Taylor,Elizabeth Thompson,Swee Lay Thein,Antonio Girolami,Maurizio De Caterina,Francesco Scopacasa,Valerio De Stefano,Giuseppe Leone,Guido Finazzi,Hannah Cohen,David A. Lane +12 more
Brief report The HBS1L-MYB intergenic region on chromosome 6q23.3 influences erythrocyte, platelet, and monocyte counts in humans
Stephan Menzel,Jie Jiang,Nicholas Silver,Joy Gallagher,Juliette Cunningham,Gabriela L. Surdulescu,Mark Lathrop,Martin Farrall,Tim D. Spector,Swee Lay Thein +9 more
TL;DR: The results support the notion that changes of F-cell abundance can be an indicator of more general shifts in hematopoietic patterns in humans, and show a significant impact of HMIP variability on several types of peripheral blood cells.
Journal ArticleDOI
ASH1L (a histone methyltransferase protein) is a novel candidate globin gene regulator revealed by genetic study of an English family with beta-thalassaemia unlinked to the beta-globin locus.
Amandine Breton,Andria Theodorou,Suleyman Aktuna,Laura Sonzogni,David Darling,Lucas Chan,Stephan Menzel,Peter J. van der Spek,Sigrid M. A. Swagemakers,Frank Grosveld,Sjaak Philipsen,Swee Lay Thein,Swee Lay Thein +12 more
TL;DR: The data suggest a putative role for ASH1L (Trithorax protein) in the regulation of globin genes, which was proposed as causative through functional mRNA knock‐down and chromatin‐immunoprecipitation studies in human erythroid progenitor cells.