S
Swee Lay Thein
Researcher at National Institutes of Health
Publications - 335
Citations - 21617
Swee Lay Thein is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Fetal hemoglobin & Population. The author has an hindex of 62, co-authored 316 publications receiving 19670 citations. Previous affiliations of Swee Lay Thein include King's College & University of Oxford.
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Journal ArticleDOI
HBS1L-MYB intergenic variants modulate fetal hemoglobin via long-range MYB enhancers.
Ralph Stadhouders,Suleyman Aktuna,Supat Thongjuea,Ali Aghajanirefah,Farzin Pourfarzad,Wilfred F. J. van IJcken,Boris Lenhard,Helen Rooks,Steve Best,Stephan Menzel,Frank Grosveld,Swee Lay Thein,Eric Soler,Eric Soler +13 more
TL;DR: It is found that several HBS1L-MYB intergenic variants reduce transcription factor binding, affecting long-range interactions with MYB and MYB expression levels, and designate MYB as a target for therapeutic induction of HbF to ameliorate sickle cell and β-thalassemia disease severity.
Journal ArticleDOI
Dissecting the loci controlling fetal haemoglobin production on chromosomes 11p and 6q by the regressive approach.
Jamie E Craig,Jacques Rochette,Chris Fisher,David J. Weatherall,S Marc,G. M. Lathrop,G. M. Lathrop,Florence Demenais,Swee Lay Thein +8 more
TL;DR: It is demonstrated that in addition to the two factors (β thalassaemia and Xmn l-Gγ site) on chromosome 11 p, there is a third major genetic determinant for fetal Hb production localized on chromosome 6q.
Journal ArticleDOI
cMYB is involved in the regulation of fetal hemoglobin production in adults
Jie Jiang,Jie Jiang,Steve Best,Stephan Menzel,Nicholas Silver,Nicholas Silver,Mei I Lai,Mei I Lai,Gabriela L. Surdulescu,Gabriela L. Surdulescu,Tim D. Spector,Swee Lay Thein +11 more
TL;DR: Observations suggest that differences in the intrinsic levels of cMYB may account for some of the variation in adult HbF levels, and the possible mechanism of c MYB influencing gamma- to beta-globin switching is discussed.
Journal Article
cMYB is involved in the regulation of fetal hemoglobin production in adults. Commentary
Susan P. Perrine,Jie Jiang,Steve Best,Stephan Menzel,Nicholas Silver,Mei I Lai,Gabriela L. Surdulescu,Tim D. Spector,Swee Lay Thein +8 more
TL;DR: In this article, a quantitative trait locus (QTL) controlling HbF levels has been mapped to chromosome 6q23 in an Asian-Indian kindred with β thalassemia and heterocellular hereditary persistence of fetal hemoglobin (HPFH).
Journal ArticleDOI
Systematic documentation and analysis of human genetic variation in hemoglobinopathies using the microattribution approach
Belinda Giardine,Joseph Borg,Joseph Borg,Douglas R. Higgs,Kenneth R. Peterson,Sjaak Philipsen,Donna Maglott,Belinda K. Singleton,D J Anstee,A. Nazli Basak,Barnaby Clark,Flávia C. Costa,Paula Faustino,Halyna Fedosyuk,Alex E. Felice,Alex E. Felice,Alain Francina,Renzo Galanello,Monica V.E. Gallivan,Marianthi Georgitsi,Richard J. Gibbons,Piero C. Giordano,Cornelis L. Harteveld,James D. Hoyer,Martin Jarvis,Philippe Joly,Emmanuel Kanavakis,Panagoula Kollia,Stephan Menzel,Webb Miller,Kamran Moradkhani,John Old,Adamantia Papachatzopoulou,Manoussos N. Papadakis,Petros Papadopoulos,Sonja Pavlovic,Lucia Perseu,Milena Radmilovic,Cathy Riemer,Stefania Satta,Iris Schrijver,Maja Stojiljkovic,Swee Lay Thein,J. Traeger-Synodinos,Raymond E. Tully,Takahito Wada,John S. Waye,Claudia Wiemann,Branka Zukic,David H.K. Chui,Henri Wajcman,Ross C. Hardison,George P. Patrinos +52 more
TL;DR: This project provides the first example of implementing microattribution to incentivise submission of all known genetic variation in a defined system and is likely to serve as a model for other systems and for the analysis of other common and/or complex human genetic diseases.