S
Swee Lay Thein
Researcher at National Institutes of Health
Publications - 335
Citations - 21617
Swee Lay Thein is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Fetal hemoglobin & Population. The author has an hindex of 62, co-authored 316 publications receiving 19670 citations. Previous affiliations of Swee Lay Thein include King's College & University of Oxford.
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Journal ArticleDOI
Assessment of clonality in gastrointestinal cancer by DNA fingerprinting.
TL;DR: In two cases of gastric cancer, DNA from the metastatic tumor had a different DNA fingerprint from that found in the primary carcinoma, and may prove useful for the study of tumor progression.
Journal ArticleDOI
A novel amino acid substitution in the reactive site of a congenital variant antithrombin. Antithrombin pescara, ARG393 to pro, caused by a CGT to CCT mutation.
David A. Lane,H Erdjument,Elizabeth Thompson,M Panico,V. Di Marzo,H R Morris,G Leone,V. De Stefano,Swee Lay Thein +8 more
TL;DR: It is demonstrated that the molecular defect of antithrombin Pescara is caused by a CGT to CCT mutation in codon 393, which may be of broad interest, as other members of the serine protease inhibitor superfamily contain arginine at their reactive sites and may be expected to undergo a similar mutation.
A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium
Nicole Soranzo,Tim D. Spector,Massimo Mangino,Brigitte Kuehnel,Augusto Rendon,Alexander Teumer,Christina Willenborg,Benjamin J. Wright,Li Chen,Mingyao Li,Perttu Salo,Benjamin F. Voight,Philippa Burns,Roman A. Laskowski,Yali Xue,Stephan Menzel,David Altshuler,John Bradley,Suzannah Bumpstead,Mary-Susan Burnett,Joseph M. Devaney,Angela Doering,Roberto Elosua,Stephen E. Epstein,Wendy N. Erber,Mario Falchi,Stephen F. Garner,Mohammed J. R. Ghori,Alison H. Goodall,Rhian Gwilliam,Hakon Hakonarson,Alistair S. Hall,Naomi Hammond,Christian Hengstenberg,Thomas Illig,Inke R. Koenig,Christopher W. Knouff,Ruth McPherson,Olle Melander,Vincent Mooser,Matthias Nauck,Markku S. Nieminen,Christopher J. O'Donnell,Leena Peltonen,Simon C. Potter,Holger Prokisch,Daniel J. Rader,Catherine M. Rice,Robert Roberts,Veikko Salomaa,Jennifer G. Sambrook,Stefan Schreiber,Heribert Schunkert,Stephen M. Schwartz,Jovana Serbanovic-Canic,Juha Sinisalo,David S. Siscovick,Klaus Stark,Ida Surakka,Jonathan Stephens,John R. Thompson,Uwe Voelker,Henry Voelzke,Nicholas A. Watkins,George A. Wells,H-Erich Wichmann,David A. van Heel,Chris Tyler-Smith,Swee Lay Thein,Sekar Kathiresan,Markus Perola,Muredach P. Reilly,Alexandre F.R. Stewart,Jeanette Erdmann,Nilesh J. Samani,Christa Meisinger,Andreas Greinacher,Panos Deloukas,Willem H. Ouwehand,Christian Gieger +79 more
TL;DR: In this article, the genetic variation in eight clinically relevant hematological parameters, including hemoglobin levels, red and white blood cell counts and platelet counts and volume, was investigated.
Journal ArticleDOI
HbA2 levels in normal adults are influenced by two distinct genetic mechanisms
TL;DR: The results suggest that HbA2 levels in adults are influenced by two different biological processes: one via kinetics of erythropoiesis, and the other, via competition between HBB and HBD activity.
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The carrier state for sickle cell disease is not completely harmless.
Julia Zhe Xu,Swee Lay Thein +1 more
TL;DR: While some of the associations historically attributed to SCT are unfounded, recent meta-analyses found high-quality evidence that SCT is indeed a risk factor for a handful of complications common to SCD.