S
Sylvain Ladame
Researcher at Imperial College London
Publications - 65
Citations - 3078
Sylvain Ladame is an academic researcher from Imperial College London. The author has contributed to research in topics: G-quadruplex & Peptide nucleic acid. The author has an hindex of 27, co-authored 61 publications receiving 2742 citations. Previous affiliations of Sylvain Ladame include Laboratory of Molecular Biology & Paul Sabatier University.
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Journal ArticleDOI
Putative DNA Quadruplex Formation within the Human c-kit Oncogene
Sarah Rankin,Anthony P. Reszka,Julian L. Huppert,Mire Zloh,Gary N. Parkinson,Alan K. Todd,Sylvain Ladame,Shankar Balasubramanian,Stephen Neidle +8 more
TL;DR: The DNA sequence, d(AGGGAGGGCGCTGGGAGG AGGAGGG), occurs within the promoter region of the c-kit oncogene and it is shown that this sequence forms a four-stranded quadruplex structure under physiological conditions.
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A Conserved Quadruplex Motif Located in a Transcription Activation Site of the Human c-kit Oncogene
Himesh Fernando,Anthony P. Reszka,Julian L. Huppert,Sylvain Ladame,Sarah Rankin,Ashok R. Venkitaraman,Stephen Neidle,Shankar Balasubramanian +7 more
TL;DR: The evidence suggests that this c-kit21 quadruplex is a serious target for a detailed functional investigation at the cell-biology level, and shows a high level of sequence conservation across human, mouse, rat, and chimpanzee.
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Dynamic combinatorial chemistry: on the road to fulfilling the promise
TL;DR: The most recent advances in the field of dynamic combinatorial chemistry that have been developed to overcome limitations and explore new areas of application are presented.
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Enhanced chemical synthesis at soft interfaces: a universal reaction-adsorption mechanism in microcompartments
Ali Fallah-Araghi,Kamel Meguellati,Jean-Christophe Baret,Abdeslam El Harrak,Thomas Mangeat,Martin Karplus,Martin Karplus,Sylvain Ladame,Sylvain Ladame,Carlos M. Marques,Andrew D. Griffiths,Andrew D. Griffiths +11 more
TL;DR: Reaction thermodynamics is modified by compartmentalization at the mesoscale--without confinement on the molecular scale--leading to a universal mechanism for improving unfavorable reactions.
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Macrocyclic and helical oligoamides as a new class of G-quadruplex ligands.
Pravin S. Shirude,Elizabeth R. Gillies,Sylvain Ladame,Frédéric Godde,Kazuo Shin-ya,Ivan Huc,Shankar Balasubramanian +6 more
TL;DR: A planar trimeric macrocyclic oligoamide of 8-amino-2-quinoline carboxylic acid, bearing ammonium side chains, stabilizes the human telomeric G-quadruplex more strongly than the potent ligand telomestatin.