Takahiro Goto

TL;DR: Results indicate that the blood glucose levels of diabetic rats can be effectively controlled by oral SS- ILP administration, and thus SS-ILP would be a promising delivery carrier of insulin via the oral route.

TL;DR: In studies with diabetic rats, the serum glucose level was lower than control values for the animals that received the insulin-loaded copolymers and lasted for at least 6 h, and the insulin loaded copolymer nanospheres caused a significant reduction of serum glucose with respect to that of a control animal.

TL;DR: The results imply that the particle size and delivery site are very important factors for ILP with respect to increasing the bioavailability of insulin following oral administration.

TL;DR: Findings indicated that the hydrogels may be a promising tool for improving oral bioavailability of various drugs, which are poorly absorbed from the GI tract.

TL;DR: A novel cytoplasmic RNA replicon capable of expressing installed genes stably without chromosome insertion is reported, which is a potentially valuable genetic platform for various biological applications.