M
Mahito Nakanishi
Researcher at National Institute of Advanced Industrial Science and Technology
Publications - 141
Citations - 6015
Mahito Nakanishi is an academic researcher from National Institute of Advanced Industrial Science and Technology. The author has contributed to research in topics: Induced pluripotent stem cell & Reprogramming. The author has an hindex of 38, co-authored 136 publications receiving 5244 citations. Previous affiliations of Mahito Nakanishi include Tokushima Bunri University & Osaka Bioscience Institute.
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Journal ArticleDOI
Development of defective and persistent Sendai virus vector: a unique gene delivery/expression system ideal for cell reprogramming.
Ken Nishimura,Masayuki Sano,Manami Ohtaka,Birei Furuta,Yoko Umemura,Yoshiro Nakajima,Yuzuru Ikehara,Toshihiro Kobayashi,Hiroaki Segawa,Satoko Takayasu,Hideyuki Sato,Kaori Motomura,Eriko Uchida,Toshie Kanayasu-Toyoda,Makoto Asashima,Hiromitsu Nakauchi,Teruhide Yamaguchi,Mahito Nakanishi +17 more
TL;DR: A novel replication-defective and persistent Sendai virus (SeVdp) vector based on a noncytopathic variant virus, which fulfills all of the requirements for cell reprogramming and for stem cell research is reported.
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Multivalent control of 3-hydroxy-3-methylglutaryl coenzyme A reductase. Mevalonate-derived product inhibits translation of mRNA and accelerates degradation of enzyme.
TL;DR: It is suggested that sterols suppress the enzyme incompletely by partially repressing transcription of the gene and that nonsterol products derived from mevalonate further reduce the enzyme by inhibiting translation of the mRNA.
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Generation of Rejuvenated Antigen-Specific T Cells by Reprogramming to Pluripotency and Redifferentiation
Toshinobu Nishimura,Shin Kaneko,Ai Kawana-Tachikawa,Yoko Tajima,Haruo Goto,Dayong Zhu,Kaori Nakayama-Hosoya,Shoichi Iriguchi,Yasushi Uemura,Takafumi Shimizu,Naoya Takayama,Daisuke Yamada,Ken Nishimura,Manami Ohtaka,Nobukazu Watanabe,Satoshi Takahashi,Aikichi Iwamoto,Haruhiko Koseki,Mahito Nakanishi,Koji Eto,Hiromitsu Nakauchi +20 more
TL;DR: This work reprogrammed clonally expanded antigen-specific CD8(+) T cells from an HIV-1-infected patient to pluripotency and found that this method can be effective for generating specific T-cells for other pathology-associated antigens.
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Protein transduction domain of HIV-1 Tat protein promotes efficient delivery of DNA into mammalian cells.
Akiko Eguchi,Teruo Akuta,Hajime Okuyama,Takao Senda,Haruhiko Yokoi,Hachiro Inokuchi,Shigeo Fujita,Takao Hayakawa,Katsuo Takeda,Mamoru Hasegawa,Mahito Nakanishi,Mahito Nakanishi +11 more
TL;DR: It is reported that the protein transduction domain of human immunodeficiency virus type 1 Tat protein (Tat peptide) greatly facilitates gene transfer via membrane destabilization and will become a useful component of synthetic delivery vehicles that promote gene transfer independently of the classical endocytic pathway.
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Transient activation of c-MYC expression is critical for efficient platelet generation from human induced pluripotent stem cells.
Naoya Takayama,Satoshi Nishimura,Satoshi Nishimura,Sou Nakamura,Takafumi Shimizu,Ryoko Ohnishi,Hiroshi Endo,Tomoyuki Yamaguchi,Makoto Otsu,Ken Nishimura,Ken Nishimura,Mahito Nakanishi,Akira Sawaguchi,Ryozo Nagai,Kazutoshi Takahashi,Shinya Yamanaka,Hiromitsu Nakauchi,Koji Eto +17 more
TL;DR: A specific kinetic pattern of c-MYC expression is essential for optimal generation of functional platelets from human induced pluripotent stem cells.