Takako Furukawa

TL;DR: Genetic and biochemical evidence is presented that Osa is a component of the Brahma complex, the Drosophila homolog of SWI/SNF, and evidence that some Brahma‐containing complexes do not contain Osa and that OsA is not required to localize Brahma to chromatin is shown.

TL;DR: The isolation of two related but distinct cDNA clones, hOsa1 and hOSA2, that encode the largest subunits of human SWI/SNF are reported, suggesting that hOSa1 andhOsa2 participate in promoting transcriptional activation by the steroid hormone receptors.

TL;DR: It is proposed that PBR play a role in the intracellular transport of porphyrins and heme, as the binding was dose-dependently inhibited by PK11195, Ro 5-4864, and diazepam, porphyrs are likely to be endogenous ligands for PBR.

TL;DR: A 3D culture system with inorganic nanoscale scaffolding using nanoimprinting technology (nano-culture plates) allows creating uniform and highly-reproducible 3D cultures, which can be used for high-throughput/high-content screening of anticancer drugs and should accelerate discovery of more effective anticancer therapies.

TL;DR: This work investigated the relation between [14C]choline metabolism and proliferative activity using 10 tumor cell lines and fibroblasts and found that choline uptake was higher in tumor cells than in fibro Blasts and was correlated with the proliferativeActivity, though the sensitivity of [14 cCholine uptake to proliferation activity was less than that of [1-14C]-acetate.