Yasushi Kiyono

TL;DR: Results indicate that the V1a receptor plays an important role in normal resting arterial BP regulation mainly by its regulation of circulating blood volume and baroreflex sensitivity.

TL;DR: Findings show that ZOL significantly stimulated the proliferation of gdγδT cells and that gdβδ T cells required pre‐treatment with ZOL for cytotoxic activity against target cells.

TL;DR: A 3D culture system with inorganic nanoscale scaffolding using nanoimprinting technology (nano-culture plates) allows creating uniform and highly-reproducible 3D cultures, which can be used for high-throughput/high-content screening of anticancer drugs and should accelerate discovery of more effective anticancer therapies.

TL;DR: It is found that tumor cells expressed higher levels of cytosolic acetyl‐CoA synthetase (ACSS2) under hypoxia than normoxia, which indicates that ACSS2 is a bi‐directional enzyme in tumor cells and that AC SS2 might play a buffering role in tumor acetyl-CoA/acetate metabolism.

TL;DR: It is demonstrated that uptake of radiolabeled acetate is a useful predictor of FASN-targeted therapy outcome, which suggests that [1-11C]acetate positron emission tomography (PET) could be a powerful tool to accomplish personalized FASn- targeted therapy by non-invasive visualization of tumor acetate uptake and selection of responsive tumors.