T
Takao Aoyagi
Researcher at Nihon University
Publications - 161
Citations - 6720
Takao Aoyagi is an academic researcher from Nihon University. The author has contributed to research in topics: Poly(N-isopropylacrylamide) & Lower critical solution temperature. The author has an hindex of 41, co-authored 161 publications receiving 6256 citations. Previous affiliations of Takao Aoyagi include Kagoshima University & National Presto Industries.
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Thermo-responsive drug delivery from polymeric micelles constructed using block copolymers of poly(N-isopropylacrylamide) and poly(butylmethacrylate).
TL;DR: Polymeric micelles incorporated with adriamycin showed a dramatic thermo-responsive on/off switching behavior for both drug release and in vitro cytotoxicity according to the temperature responsive structural changes of a micellar shell structure.
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Rapid Deswelling Response of Poly(N-isopropylacrylamide) Hydrogels by the Formation of Water Release Channels Using Poly(ethylene oxide) Graft Chains
Yuzo Kaneko,Satoki Nakamura,Kiyotaka Sakai,Takao Aoyagi,Akihiko Kikuchi,Yasuhisa Sakurai,Teruo Okano +6 more
TL;DR: In this paper, the deswelling response on raising the temperature of this gel above the gel phase transition temperature (TP) takes place within 10 min, whereas a conventionally cross-linked PIPAAm gel of the same dimensions requires 1 month.
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Preparation and characterization of thermally responsive block copolymer micelles comprising poly(N-isopropylacrylamide-b-DL-lactide).
TL;DR: The thermally sensitive block copolymer system synthesized by ring-opening polymerization of dl-lactide initiated from hydroxy-terminated poly (N-isopropylacrylamide) (PIPAAm-PLA) is interesting from both applied and fundamental perspectives, particularly for active targeting as drug carriers.
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Preparation and Characterization of Self-Assembled Polymer−Metal Complex Micelle from cis-Dichlorodiammineplatinum(II) and Poly(ethylene glycol)−Poly(α,β-aspartic acid) Block Copolymer in an Aqueous Medium
Nobuhiro Nishiyama,Masayuki Yokoyama,Takao Aoyagi,Teruo Okano,Yasuhisa Sakurai,Kazunori Kataoka +5 more
TL;DR: In this article, the critical substitution molar ratio of CDDP to Asp residues in PEG−P(Asp) to form a stable micelle structure was determined to be 0.5 and the CDDP-complexed micelle started to dissociate in approximately 10 h of the induction period accompanying the sustained release of platinum(II) complex from the micelle in physiological saline (0.15 M NaCl solution) at 37 °C.
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A Smart Hyperthermia Nanofiber with Switchable Drug Release for Inducing Cancer Apoptosis
TL;DR: In this article, a smart hyperthermia nanofiber is described with simultaneous heat generation and drug release in response to "on-off" switching of alternating magnetic field (AMF) for induction of skin cancer apoptosis.