T
Takao Takahashi
Researcher at University of Texas Southwestern Medical Center
Publications - 20
Citations - 3913
Takao Takahashi is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: DNA methylation & Methylation. The author has an hindex of 15, co-authored 20 publications receiving 3721 citations. Previous affiliations of Takao Takahashi include Gifu University & University of Texas at Dallas.
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Journal ArticleDOI
Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers
Hisayuki Shigematsu,Hisayuki Shigematsu,Li Lin,Takao Takahashi,Masaharu Nomura,Makoto Suzuki,Ignacio I. Wistuba,Kwun M. Fong,Huei Lee,Shinichi Toyooka,Nobuyoshi Shimizu,Takehiko Fujisawa,Ziding Feng,Jack A. Roth,Joachim Herz,John D. Minna,Adi F. Gazdar +16 more
TL;DR: EGFR TK domain mutations are the first molecular change known to occur specifically in never smokers, and can lead to lung cancer pathogenesis.
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Somatic mutations of the HER2 kinase domain in lung adenocarcinomas
Hisayuki Shigematsu,Hisayuki Shigematsu,Takao Takahashi,Masaharu Nomura,Kuntal Majmudar,Makoto Suzuki,Huei Lee,Ignacio I. Wistuba,Kwun M. Fong,Shinichi Toyooka,Nobuyoshi Shimizu,Takehiko Fujisawa,John D. Minna,Adi F. Gazdar +13 more
TL;DR: The remarkable similarities of mutations in EGFR and HER2 genes involving tumor type and subtype, mutation type, gene location, and specific patient subpopulations targeted are unprecedented and suggest similar etiologic factors.
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Aberrant methylation of trail decoy receptor genes is frequent in multiple tumor types
Narayan Shivapurkar,Shinichi Toyooka,Kiyomi O. Toyooka,Jyotsna Reddy,Kuniharu Miyajima,Makoto Suzuki,Hisayuki Shigematsu,Takao Takahashi,Gunjan Parikh,Harvey I. Pass,Preet M. Chaudhary,Adi F. Gazdar +11 more
TL;DR: DcR1 and DcR2 genes are frequently methylated in various tumor types, and that the role of decoy receptors in tumor pathogenesis needs to be re‐evaluated.
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Polymorphisms, Mutations, and Amplification of the EGFR Gene in Non-Small Cell Lung Cancers
Masaharu Nomura,Hisayuki Shigematsu,Lin Li,Makoto Suzuki,Takao Takahashi,Pila Estess,Mark H. Siegelman,Ziding Feng,Harubumi Kato,Antonio Marchetti,Jerry W. Shay,Margaret R. Spitz,Ignacio I. Wistuba,John D. Minna,Adi F. Gazdar +14 more
TL;DR: The three polymorphisms associated with increased EGFR protein production were found to be rare in East Asians as compared to other ethnicities, suggesting that the cells of East Asians may make relatively less intrinsic EGFRprotein.
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Aberrant Promoter Hypermethylation of Multiple Genes in Gallbladder Carcinoma and Chronic Cholecystitis
Takao Takahashi,Narayan Shivapurkar,Erick Riquelme,Hisayuki Shigematsu,Jyotsna Reddy,Makoto Suzuki,Kuniharu Miyajima,Xian Zhou,B. Nebiyou Bekele,Adi F. Gazdar,Ignacio I. Wistuba,Ignacio I. Wistuba +11 more
TL;DR: The finding of methylation in CC cases without cancer suggests that this phenomenon represents an early event in the pathogenesis of GBC, and demonstrates that this neoplasm has a distinct pattern of abnormal gene methylation.