T
Takashi Hirota
Researcher at Okayama University
Publications - 224
Citations - 1459
Takashi Hirota is an academic researcher from Okayama University. The author has contributed to research in topics: Ring (chemistry) & Formamide. The author has an hindex of 18, co-authored 224 publications receiving 1414 citations. Previous affiliations of Takashi Hirota include Kumamoto University & Nagasaki University.
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Journal ArticleDOI
Inhibition ofE. coli growth by fullerene derivatives and inhibition mechanism
Tadahiko Mashino,Kensuke Okuda,Takashi Hirota,Masaaki Hirobe,Tetsuo Nagano,Masataka Mochizuki +5 more
TL;DR: Inhibition of energy metabolism is concluded to be a mechanism of the growth inhibition effect of fullerene derivatives.
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Action mechanism of amphipathic peptides gramicidin S and melittin on erythrocyte membrane
Takashi Katsu,Chiaki Ninomiya,Masakazu Kuroko,Hideki Kobayashi,Takashi Hirota,Yuzaburo Fujita +5 more
TL;DR: The present results show that both the peptides have the ability to stimulate the release of membrane fragments out of the cells and this brings about the perforation of molecules of small size, leading to a colloid-osmotic hemolysis.
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Respiratory chain inhibition by fullerene derivatives: hydrogen peroxide production caused by fullerene derivatives and a respiratory chain system
TL;DR: The fullerene derivative C(60)-bis(N,N-dimethylpyrrolidinium iodide), a regio isomer mixture, inhibited Escherichia coli growth and dioxygen uptake caused by E. coli and glucose, indicating that the mechanism of the bacteriostatic effect is the inhibition of energy metabolism.
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Syntheses of 3-substituted 1-methyl-6-phenylpyrimido[5,4-e]-1,2,4-triazine-5,7(1H,6H)-diones (6-phenyl analogs of toxoflavin) and their 4-oxides, and evaluation of antimicrobial activity of toxoflavins and their analogs.
Tomohisa Nagamatsu,Hirofumi Yamasaki,Takashi Hirota,Masatoshi Yamato,Yutaka Kido,Motoo Shibata,Fumio Yoneda +6 more
TL;DR: 6-Phenyl analogs of toxoflavin (1-methyl-6-phenylpyrimido[5,4-e]-1,2, 4-triazine-5,7(1H,6H)-diones ) (7a--f) and their 4-oxides (8a- f) were synthesized by nitrosative or nitrative cyclization of the aldehyde hydrazones (6a-f) of
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Structure-activity relationship of gramicidin S analogues on membrane permeability
TL;DR: It was concluded that, if peptides can expand greatly the membrane structure of neutral lipids which constitute main parts of the biological membrane, they can stimulate the permeability of cells without any selectivity.