T
Takaya Murakami
Researcher at National Institutes of Health
Publications - 8
Citations - 923
Takaya Murakami is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Antigen & ZAP70. The author has an hindex of 5, co-authored 6 publications receiving 846 citations. Previous affiliations of Takaya Murakami include Science Applications International Corporation.
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Journal ArticleDOI
Uptake through glycoprotein 2 of FimH(+) bacteria by M cells initiates mucosal immune response.
Koji Hase,Kazuya Kawano,Tomonori Nochi,Gemilson Soares Pontes,Shinji Fukuda,Masashi Ebisawa,Kazunori Kadokura,Toru Tobe,Yumiko Fujimura,Sayaka Kawano,Atsuko Yabashi,Satoshi Waguri,Gaku Nakato,Shunsuke Kimura,Takaya Murakami,Mitsutoshi Iimura,Kimiyo Hamura,Shin Ichi Fukuoka,Anson W. Lowe,Kikuji Itoh,Hiroshi Kiyono,Hiroshi Ohno +21 more
TL;DR: GP2 is a previously unrecognized transcytotic receptor on M cells for type-I-piliated bacteria and is a prerequisite for the mucosal immune response to these bacteria, which could provide a new target for the development of M-cell-targeted mucosal vaccines.
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Differential response of murine CD4+CD25+ and CD4+CD25– T cells to dexamethasone‐induced cell death
TL;DR: The results suggest that, in addition to suppressing cytokine transcription, Dex treatment is permissive for the survival of functional CD4+CD25+ T regulatory cells, and this property may contribute to the anti‐inflammatory and immunosuppressive efficacy of glucocorticoids.
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The Membrane-Bound Chemokine CXCL16 Expressed on Follicle-Associated Epithelium and M Cells Mediates Lympho-Epithelial Interaction in GALT
Koji Hase,Takaya Murakami,Hiroyuki Takatsu,Takeshi Shimaoka,Mitsutoshi Iimura,Kimiyo Hamura,Kazuya Kawano,Sayaka Ohshima,Risa Chihara,Kikuji Itoh,Shin Yonehara,Hiroshi Ohno +11 more
TL;DR: The data suggest that CXCL16 expressed on the follicle-associated epithelium plays an important role in the recruitment and retention of activated T cells in the SED and should, at least partially, be responsible for lymphocyte compartmentalization in GALT.
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Triptolide, a constituent of immunosuppressive Chinese herbal medicine, is a potent suppressor of dendritic-cell maturation and trafficking
Xin Chen,Takaya Murakami,Takaya Murakami,Joost J. Oppenheim,Joost J. Oppenheim,O. M. Zack Howard,O. M. Zack Howard +6 more
TL;DR: Data provide new insight into the mechanism of action of TPT and indicate that the inhibition of maturation and trafficking of DCs by TPT contributes to its immunosuppressive effects.
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Splenic CD19-CD35+B220+ cells function as an inducer of follicular dendritic cell network formation
TL;DR: It is demonstrated that murine splenic CD19(-)-CD11c(-)CD35(+)B220(+) cells, together with stromal cells, had the remarkable ability to form lymphoid-follicle-like structures that contained B 220(+)FDC-M1(+) reticular cells originally derived from CD19(-)