K
Kikuji Itoh
Researcher at University of Tokyo
Publications - 147
Citations - 14624
Kikuji Itoh is an academic researcher from University of Tokyo. The author has contributed to research in topics: Campylobacter jejuni & Bacteroides. The author has an hindex of 39, co-authored 147 publications receiving 12852 citations. Previous affiliations of Kikuji Itoh include Keio University.
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Journal ArticleDOI
Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria
Ivaylo I. Ivanov,Koji Atarashi,Nicolas Manel,Eoin L. Brodie,Tatsuichiro Shima,Ulas Karaoz,Dongguang Wei,Katherine C. Goldfarb,Clark A. Santee,Susan V. Lynch,Takeshi Tanoue,Akemi Imaoka,Kikuji Itoh,Kiyoshi Takeda,Yoshinori Umesaki,Kenya Honda,Dan R. Littman +16 more
TL;DR: The authors showed that colonisation of mice with a segmented filamentous bacterium (SFB) is sufficient to induce the appearance of CD4+ T helper cells that produce IL-17 and IL-22 (Th17 cells) in the lamina propria.
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Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species
Koji Atarashi,Takeshi Tanoue,Tatsuichiro Shima,Akemi Imaoka,Tomomi Kuwahara,Yoshika Momose,Genhong Cheng,Sho Yamasaki,Takashi Saito,Yusuke Ohba,Tadatsugu Taniguchi,Kiyoshi Takeda,Shohei Hori,Ivaylo I. Ivanov,Yoshinori Umesaki,Kikuji Itoh,Kenya Honda,Kenya Honda +17 more
TL;DR: Oral inoculation of Clostridium during the early life of conventionally reared mice resulted in resistance to colitis and systemic immunoglobulin E responses in adult mice, suggesting a new therapeutic approach to autoimmunity and allergy.
Journal ArticleDOI
Bifidobacteria can protect from enteropathogenic infection through production of acetate
Shinji Fukuda,Hidehiro Toh,Koji Hase,Kenshiro Oshima,Yumiko Nakanishi,Kazutoshi Yoshimura,Toru Tobe,Julie M. Clarke,David L. Topping,Tohru Suzuki,Todd D. Taylor,Kikuji Itoh,Jun Kikuchi,Jun Kikuchi,Hidetoshi Morita,Masahira Hattori,Hiroshi Ohno,Hiroshi Ohno +17 more
TL;DR: It is proposed that acetate produced by protective bifidobacteria improves intestinal defence mediated by epithelial cells and thereby protects the host against lethal infection.
Journal ArticleDOI
Comparative Metagenomics Revealed Commonly Enriched Gene Sets in Human Gut Microbiomes
Ken Kurokawa,Takehiko Itoh,Tomomi Kuwahara,Kenshiro Oshima,Hidehiro Toh,Atsushi Toyoda,Hideto Takami,Hidetoshi Morita,Vineet K. Sharma,Tulika P. Srivastava,Todd D. Taylor,Hideki Noguchi,Hiroshi Mori,Yoshitoshi Ogura,Dusko S. Ehrlich,Kikuji Itoh,Toshihisa Takagi,Yoshiyuki Sakaki,Tetsuya Hayashi,Masahira Hattori,Masahira Hattori +20 more
TL;DR: This article performed a large-scale comparative metagenomic analysis of fecal samples from 13 healthy individuals of various ages, including unweaned infants, to identify the genomic features common to all human gut microbiomes as well as those variable among them.
Journal ArticleDOI
Uptake through glycoprotein 2 of FimH(+) bacteria by M cells initiates mucosal immune response.
Koji Hase,Kazuya Kawano,Tomonori Nochi,Gemilson Soares Pontes,Shinji Fukuda,Masashi Ebisawa,Kazunori Kadokura,Toru Tobe,Yumiko Fujimura,Sayaka Kawano,Atsuko Yabashi,Satoshi Waguri,Gaku Nakato,Shunsuke Kimura,Takaya Murakami,Mitsutoshi Iimura,Kimiyo Hamura,Shin Ichi Fukuoka,Anson W. Lowe,Kikuji Itoh,Hiroshi Kiyono,Hiroshi Ohno +21 more
TL;DR: GP2 is a previously unrecognized transcytotic receptor on M cells for type-I-piliated bacteria and is a prerequisite for the mucosal immune response to these bacteria, which could provide a new target for the development of M-cell-targeted mucosal vaccines.