T
Toru Tobe
Researcher at Osaka University
Publications - 48
Citations - 5028
Toru Tobe is an academic researcher from Osaka University. The author has contributed to research in topics: Virulence & Escherichia coli. The author has an hindex of 24, co-authored 44 publications receiving 4432 citations.
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Journal ArticleDOI
Bifidobacteria can protect from enteropathogenic infection through production of acetate
Shinji Fukuda,Hidehiro Toh,Koji Hase,Kenshiro Oshima,Yumiko Nakanishi,Kazutoshi Yoshimura,Toru Tobe,Julie M. Clarke,David L. Topping,Tohru Suzuki,Todd D. Taylor,Kikuji Itoh,Jun Kikuchi,Jun Kikuchi,Hidetoshi Morita,Masahira Hattori,Hiroshi Ohno,Hiroshi Ohno +17 more
TL;DR: It is proposed that acetate produced by protective bifidobacteria improves intestinal defence mediated by epithelial cells and thereby protects the host against lethal infection.
Journal ArticleDOI
Uptake through glycoprotein 2 of FimH(+) bacteria by M cells initiates mucosal immune response.
Koji Hase,Kazuya Kawano,Tomonori Nochi,Gemilson Soares Pontes,Shinji Fukuda,Masashi Ebisawa,Kazunori Kadokura,Toru Tobe,Yumiko Fujimura,Sayaka Kawano,Atsuko Yabashi,Satoshi Waguri,Gaku Nakato,Shunsuke Kimura,Takaya Murakami,Mitsutoshi Iimura,Kimiyo Hamura,Shin Ichi Fukuoka,Anson W. Lowe,Kikuji Itoh,Hiroshi Kiyono,Hiroshi Ohno +21 more
TL;DR: GP2 is a previously unrecognized transcytotic receptor on M cells for type-I-piliated bacteria and is a prerequisite for the mucosal immune response to these bacteria, which could provide a new target for the development of M-cell-targeted mucosal vaccines.
Journal ArticleDOI
An extensive repertoire of type III secretion effectors in Escherichia coli O157 and the role of lambdoid phages in their dissemination
Toru Tobe,Scott A. Beatson,Scott A. Beatson,Hisaaki Taniguchi,Hiroyuki Abe,Christopher M. Bailey,Amanda Fivian,Rasha Younis,Sophie A. Matthews,Olivier Marchès,Gad Frankel,Gad Frankel,Tetsuya Hayashi,Mark J. Pallen +13 more
TL;DR: Binformatics and experimental approaches are exploited to establish that the effector repertoire in the Sakai strain of enterohemorrhagic E. coli (EHEC) O157:H7 is much larger than previously thought.
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Comparative genomics reveal the mechanism of the parallel evolution of O157 and non-O157 enterohemorrhagic Escherichia coli
Yoshitoshi Ogura,Tadasuke Ooka,Atsushi Iguchi,Hidehiro Toh,Asadulghani,Kenshiro Oshima,Toshio Kodama,Hiroyuki Abe,Keisuke Nakayama,Ken Kurokawa,Toru Tobe,Masahira Hattori,Tetsuya Hayashi +12 more
TL;DR: A genomic comparison between EHECs of serotype O157, O26, O111, and O103, as well as 21 other, fully sequenced E. coli/Shigella strains, finds many lambdoid phages, IEs, and virulence plasmids that carry the same or similar virulence genes but have distinct evolutionary histories, indicating that independent acquisition of these mobile genetic elements has driven the evolution of each EH EC.
Journal ArticleDOI
NleC, a type III secretion protease, compromises NF-κB activation by targeting p65/RelA.
TL;DR: It is found that NleC is an anti-inflammatory bacterial zinc protease that disrupts NF-κB activation by the direct cleavage of NF-KKB's p65 subunit in the cytoplasm, thereby decreasing the available p65 and reducing the total nuclear entry of active p65.