T
Takeshi Imai
Researcher at Tokyo Institute of Technology
Publications - 61
Citations - 2479
Takeshi Imai is an academic researcher from Tokyo Institute of Technology. The author has contributed to research in topics: Medicine & Retinoid X receptor. The author has an hindex of 21, co-authored 54 publications receiving 2302 citations. Previous affiliations of Takeshi Imai include Nihon University & National Institute for Basic Biology, Japan.
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Journal ArticleDOI
Dsif, a novel transcription elongation factor that regulates rna polymerase ii processivity, is composed of human spt4 and spt5 homologs
Tadashi Wada,Toshiyuki Takagi,Yuki Yamaguchi,Anwarul Ferdous,Takeshi Imai,Susumu Hirose,Seiji Sugimoto,Keiichi Yano,Grant A. Hartzog,Fred Winston,Stephen Buratowski,Hiroshi Handa +11 more
TL;DR: The combination of biochemical studies on DSIF and genetic analysis of Spt4 and Spt5 in yeast indicates that DSIF associates with RNA Pol II and regulates its processivity in vitro and in vivo.
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Peroxisome proliferator-activated receptor γ is required in mature white and brown adipocytes for their survival in the mouse
Takeshi Imai,Reiko Takakuwa,Sandra Marchand,Emilie Dentz,Jean-Marc Bornert,Nadia Messaddeq,Olivia Wendling,Manuel Mark,Béatrice Desvergne,Walter Wahli,Pierre Chambon,Daniel Metzger +11 more
TL;DR: It is shown that mature PPARGamma-null white and brown adipocytes die within a few days and are replaced by newly formed PPARgamma-positive adipocytes, demonstrating that PPargamma is essential for the in vivo survival of mature adipocyte survival, in addition to its well established requirement for their differentiation.
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Impaired adipogenesis and lipolysis in the mouse upon selective ablation of the retinoid X receptor alpha mediated by a tamoxifen-inducible chimeric Cre recombinase (Cre-ERT2) in adipocytes.
TL;DR: The data demonstrate the feasibility of adipocyte-selective temporally controlled gene engineering and reveal a central role of RXRα in adipogenesis, probably as a heterodimeric partner for peroxisome proliferator-activated receptor γ.
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The Role of Human MBF1 as a Transcriptional Coactivator
Yasuaki Kabe,Masahide Goto,Daisuke Shima,Takeshi Imai,Tadashi Wada,Ken Ichirou Morohashi,Masahiro Shirakawa,Susumu Hirose,Hiroshi Handa +8 more
TL;DR: The cDNA cloning and functional analysis of hMBF1 establish that the coactivator MBF1 is functionally conserved in eukaryotes.
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Isolation of a cDNA encoding the largest subunit of TFIIA reveals functions important for activated transcription.
Dongmin Ma,Hajime Watanabe,Fred Mermelstein,Arie Admon,K Oguri,Xiaoqing Sun,Tadashi Wada,Takeshi Imai,T. Shiroya,Danny Reinberg +9 more
TL;DR: Functional assays establish that TFIIA has no apparent role in basal transcription but plays an important role in activation of transcription and studies using antibodies raised against recombinant alpha polypeptide demonstrate that T FIIA can be an integral component of the preinitiation complex.