T
Toshifumi Morimura
Researcher at Shiga University of Medical Science
Publications - 20
Citations - 2618
Toshifumi Morimura is an academic researcher from Shiga University of Medical Science. The author has contributed to research in topics: Phosphorylation & Reelin. The author has an hindex of 12, co-authored 17 publications receiving 2293 citations. Previous affiliations of Toshifumi Morimura include University of Tokyo & RIKEN Brain Science Institute.
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Journal ArticleDOI
Visualizing Spatiotemporal Dynamics of Multicellular Cell-Cycle Progression
Asako Sakaue-Sawano,Hiroshi Kurokawa,Toshifumi Morimura,Aki Hanyu,Hiroshi Hama,Hatsuki Osawa,Saori Kashiwagi,Kiyoko Fukami,Takaki Miyata,Hiroyuki Miyoshi,Takeshi Imamura,Masaharu Ogawa,Hisao Masai,Atsushi Miyawaki +13 more
TL;DR: Time-lapse imaging is performed to explore the spatiotemporal patterns of cell-cycle dynamics during the epithelial-mesenchymal transition of cultured cells, the migration and differentiation of neural progenitors in brain slices, and the development of tumors across blood vessels in live mice.
Journal ArticleDOI
Cell cycle arrest and apoptosis induced by Notch1 in B cells.
Toshifumi Morimura,Ryo Goitsuka,Ryo Goitsuka,Yong Zhang,Izumu Saito,Michael Reth,Daisuke Kitamura +6 more
TL;DR: Notch1 signaling induces apoptosis of the B cells through Hairy1, and the G1 cell cycle arrest through other pathways, which may account for the recent observations indicating the selective inhibition of early B cell development in mice by Notch1.
Journal ArticleDOI
Regulation of actin cytoskeleton by mDab1 through N-WASP and ubiquitination of mDab1.
Shiro Suetsugu,Tohru Tezuka,Toshifumi Morimura,Toshifumi Morimura,Mitsuharu Hattori,Katsuhiko Mikoshiba,Katsuhiko Mikoshiba,Tadashi Yamamoto,Tadaomi Takenawa +8 more
TL;DR: It is shown that mDab1 associates with N-WASP (neuronal Wiskott-Aldrich syndrome protein) in vitro and in brains of embryonic mice, which suggests that m Dab1 regulates the actin cytoskeleton through N-wASP, which is negatively regulated by phosphorylation-mediated ubiquitination of mDAb1.
Journal ArticleDOI
Disabled1 Regulates the Intracellular Trafficking of Reelin Receptors
TL;DR: Results indicate that Dab1 regulates both cell surface expression and internalization of Reelin receptors, and these regulations may play a role in correct laminar formation in the developing brain.
Journal ArticleDOI
Aberrant Assembly of RNA Recognition Motif 1 Links to Pathogenic Conversion of TAR DNA-binding Protein of 43 kDa (TDP-43)
Akemi Shodai,Toshifumi Morimura,Akemi Ido,Tsukasa Uchida,Tsukasa Uchida,Takashi Ayaki,Rina Takahashi,Soichiro Kitazawa,S. Suzuki,Mikako Shirouzu,Takanori Kigawa,Yutaka Muto,Shigeyuki Yokoyama,Ryosuke Takahashi,Ryo Kitahara,Hidefumi Ito,Hidefumi Ito,Noriko Fujiwara,Makoto Urushitani +18 more
TL;DR: The results indicate that cysteines in RRM1 crucially govern the conformation of TDP-43, and aberrant self-assembly ofRRM1 at amyloidogenic regions contributes to pathogenic conversion of T DP-43 in ALS.