T
Takeshi Tokuhisa
Researcher at Chiba University
Publications - 175
Citations - 13428
Takeshi Tokuhisa is an academic researcher from Chiba University. The author has contributed to research in topics: Antigen & T cell. The author has an hindex of 50, co-authored 173 publications receiving 12788 citations.
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Journal ArticleDOI
The role of autophagy during the early neonatal starvation period
Akiko Kuma,Masahiko Hatano,Makoto Matsui,Makoto Matsui,Akitsugu Yamamoto,Haruaki Nakaya,Tamotsu Yoshimori,Yoshinori Ohsumi,Takeshi Tokuhisa,Noboru Mizushima,Noboru Mizushima,Noboru Mizushima +11 more
TL;DR: The results suggest that the production of amino acids by autophagic degradation of ‘self’ proteins, which allows for the maintenance of energy homeostasis, is important for survival during neonatal starvation.
Journal ArticleDOI
Dissection of Autophagosome Formation Using Apg5-Deficient Mouse Embryonic Stem Cells
Noboru Mizushima,Noboru Mizushima,Akitsugu Yamamoto,Masahiko Hatano,Yoshinori Kobayashi,Yoshinori Kobayashi,Yukiko Kabeya,Kuninori Suzuki,Kuninori Suzuki,Takeshi Tokuhisa,Yoshinori Ohsumi,Yoshinori Ohsumi,Tamotsu Yoshimori,Tamotsu Yoshimori +13 more
TL;DR: It is shown that mouse Apg12-Apg5 conjugate localizes to the isolation membranes in mouse embryonic stem cells, and the covalent modification of Apg5 with Apg 12 is not required for its membrane targeting, but is essential for involvement of ApG5 in elongation of the isolation membrane.
Journal ArticleDOI
Hematopoietic stem cells differentiate into vascular cells that participate in the pathogenesis of atherosclerosis
Masataka Sata,Akio Saiura,Atsushi Kunisato,Akihiro Tojo,Seiji Okada,Takeshi Tokuhisa,Hisamaru Hirai,Masatoshi Makuuchi,Yasunobu Hirata,Ryozo Nagai +9 more
TL;DR: It is shown that in models of post-angioplasty restenosis, graft vasculopathy and hyperlipidemia-induced atherosclerosis, bone-marrow cells give rise to most of the SMCs that contribute to arterial remodeling, indicating that somatic stem cells contribute to pathological remodeling of remote organs.
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IL-23 and Th17 Cells Enhance Th2-Cell–mediated Eosinophilic Airway Inflammation in Mice
Hidefumi Wakashin,Koichi Hirose,Yuko Maezawa,Shin-ichiro Kagami,Akira Suto,Norihiko Watanabe,Yasushi Saito,Masahiko Hatano,Takeshi Tokuhisa,Yoichiro Iwakura,Paolo Puccetti,Itsuo Iwamoto,Hiroshi Nakajima +12 more
TL;DR: IL-23 and Th17 cells not only induce Th17-cell-mediated neutrophilic airway inflammation but also up-regulate Th2- cell-mediated eosinophil recruitment into the airways and airway hyperresponsiveness.
Journal ArticleDOI
Disruption of the Bcl6 Gene Results in an Impaired Germinal Center Formation
Tetsuya Fukuda,Takehiko Yoshida,Seiji Okada,Masahiko Hatano,Tohru Miki,Kazuki Ishibashi,Shinichiro Okabe,Haruhiko Koseki,Shinsaku Hirosawa,Masaru Taniguchi,Nobuyuki Miyasaka,Takeshi Tokuhisa +11 more
TL;DR: Bcl6 is essential for the differentiation of GC B cells, and its products are expressed highly in germinal center (GC) B cells.