T
Taki Nishimura
Researcher at University College London
Publications - 29
Citations - 2070
Taki Nishimura is an academic researcher from University College London. The author has contributed to research in topics: Autophagy & Autophagosome. The author has an hindex of 16, co-authored 23 publications receiving 1676 citations. Previous affiliations of Taki Nishimura include Tokyo Medical and Dental University & Francis Crick Institute.
Papers
More filters
Journal ArticleDOI
De novo mutations in the autophagy gene WDR45 cause static encephalopathy of childhood with neurodegeneration in adulthood
Hirotomo Saitsu,Taki Nishimura,Taki Nishimura,Kazuhiro Muramatsu,Hirofumi Kodera,Satoko Kumada,Kenji Sugai,Emi Kasai-Yoshida,Noriko Sawaura,Hiroya Nishida,Ai Hoshino,Fukiko Ryujin,Seiichiro Yoshioka,Kiyomi Nishiyama,Yukiko Kondo,Yoshinori Tsurusaki,Mitsuko Nakashima,Noriko Miyake,Hirokazu Arakawa,Mitsuhiro Kato,Noboru Mizushima,Noboru Mizushima,Naomichi Matsumoto +22 more
TL;DR: Findings provide direct evidence that an autophagy defect is indeed associated with a neurodegenerative disorder in humans.
Journal ArticleDOI
The HOPS complex mediates autophagosome–lysosome fusion through interaction with syntaxin 17
Peidu Jiang,Taki Nishimura,Taki Nishimura,Yuriko Sakamaki,Eisuke Itakura,Tomohisa Hatta,Tohru Natsume,Noboru Mizushima,Noboru Mizushima +8 more
TL;DR: Syntaxin 17 interacts with the HOPS-tethering complex, which is required for syntaxin 17–dependent autophagosome–lysosome fusion, besides its function in endolysosomal fusion.
Journal ArticleDOI
Mammalian Atg2 proteins are essential for autophagosome formation and important for regulation of size and distribution of lipid droplets
Anoop Kumar G. Velikkakath,Taki Nishimura,Eiko Oita,Naotada Ishihara,Naotada Ishihara,Noboru Mizushima +5 more
TL;DR: Mammalian AtG2 proteins Atg2A and Atg1B are identified and characterized as essential for autophagy and are involved in regulation of lipid droplet volume and distribution.
Journal ArticleDOI
FIP200 regulates targeting of Atg16L1 to the isolation membrane
Taki Nishimura,Taki Nishimura,Takeshi Kaizuka,Ken Cadwell,Ken Cadwell,Mayurbhai Himatbhai Sahani,Tatsuya Saitoh,Shizuo Akira,Herbert W. Virgin,Noboru Mizushima,Noboru Mizushima +10 more
TL;DR: It is found that FIP200, which is involved in proximal events, directly interacts with Atg16L1, one of the downstream Atg factors, in an Atg14‐ and phosphatidylinositol 3‐kinase‐independent manner.
Journal ArticleDOI
Autophagosome formation is initiated at phosphatidylinositol synthase-enriched ER subdomains.
Taki Nishimura,Norito Tamura,Norito Tamura,Nozomu Kono,Yuta Shimanaka,Hiroyuki Arai,Hiroyuki Arai,Hayashi Yamamoto,Noboru Mizushima +8 more
TL;DR: Biochemically analyze autophagic intermediate membranes and suggest that the autophagy‐initiation complex, the PIS‐enriched ER subdomain, and ATG9A vesicles together initiate autophagosome formation.