T
Talal A. Chatila
Researcher at Boston Children's Hospital
Publications - 278
Citations - 24036
Talal A. Chatila is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: FOXP3 & T cell. The author has an hindex of 74, co-authored 255 publications receiving 20567 citations. Previous affiliations of Talal A. Chatila include Brigham and Women's Hospital & University of California, Los Angeles.
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Journal ArticleDOI
The Toll-Like Receptor 2 Pathway Establishes Colonization by a Commensal of the Human Microbiota
June L. Round,S. Melanie Lee,Jennifer S. Li,Gloria Tran,Bana Jabri,Talal A. Chatila,Sarkis K. Mazmanian +6 more
TL;DR: It is proposed that the immune system can discriminate between pathogens and the microbiota through recognition of symbiotic bacterial molecules in a process that engenders commensal colonization.
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JM2, encoding a fork head–related protein, is mutated in X-linked autoimmunity–allergic disregulation syndrome
Talal A. Chatila,Frank Blaeser,Nga Ho,Howard M. Lederman,Constantine Voulgaropoulos,Cindy Helms,Anne M. Bowcock +6 more
TL;DR: The results point to a critical role for JM2 in self tolerance and Th cell differentiation, and one point mutation at a splice junction site results in transcripts that encode a truncated protein lacking the fork head homology domain.
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Human Inborn Errors of Immunity: 2019 Update on the Classification from the International Union of Immunological Societies Expert Committee
Stuart G. Tangye,Waleed Al-Herz,Aziz Bousfiha,Talal A. Chatila,Charlotte Cunningham-Rundles,Amos Etzioni,José Luis Franco,Steven M. Holland,Christoph Klein,Tomohiro Morio,Hans D. Ochs,Eric Oksenhendler,Capucine Picard,Jennifer M. Puck,Troy R. Torgerson,Jean-Laurent Casanova,Kathleen E. Sullivan +16 more
TL;DR: This report documents the key clinical and laboratory features of 430 inborn errors of immunity, including 64 gene defects that have either been discovered in the past 2 years since the previous update (published January 2018) or were characterized earlier but have since been confirmed or expanded upon in subsequent studies.
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Primary Immunodeficiency Diseases: an Update on the Classification from the International Union of Immunological Societies Expert Committee for Primary Immunodeficiency 2015
Capucine Picard,Waleed Al-Herz,Aziz Bousfiha,Jean-Laurent Casanova,Talal A. Chatila,Mary Ellen Conley,Charlotte Cunningham-Rundles,Amos Etzioni,Steven M. Holland,Christoph Klein,Shigeaki Nonoyama,Hans D. Ochs,Eric Oksenhendler,Jennifer M. Puck,Kathleen E. Sullivan,Mimi L.K. Tang,Mimi L.K. Tang,José Luis Franco,H. Bobby Gaspar +18 more
TL;DR: The most up-to-date catalogue of all known and published primary immunodeficiencies and acts as a current reference of the knowledge of these conditions and is an important aid for the genetic and molecular diagnosis of patients with these rare diseases.
Journal ArticleDOI
The association of atopy with a gain-of-function mutation in the alpha subunit of the interleukin-4 receptor.
Gurjit K. Khurana Hershey,Michal F. Friedrich,Laura A. Esswein,Matthew L. Thomas,Talal A. Chatila +4 more
TL;DR: The R576 allele of interleukin-4 receptor alpha is strongly associated with atopy, and this mutation may predispose persons to allergic diseases by altering the signaling function of the receptor.