T
Tamara Copetti
Researcher at Université catholique de Louvain
Publications - 19
Citations - 2556
Tamara Copetti is an academic researcher from Université catholique de Louvain. The author has contributed to research in topics: Autophagy & Glycolysis. The author has an hindex of 16, co-authored 19 publications receiving 2163 citations. Previous affiliations of Tamara Copetti include Catholic University of Leuven & AREA Science Park.
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Journal ArticleDOI
A Mitochondrial Switch Promotes Tumor Metastasis
Paolo E. Porporato,Valéry Payen,Jhudit Pérez-Escuredo,Christophe De Saedeleer,Pierre Danhier,Tamara Copetti,Suveera Dhup,Morgane Tardy,Thibaut Vazeille,Caroline Bouzin,Olivier Feron,Carine Michiels,Bernard Gallez,Pierre Sonveaux +13 more
TL;DR: Two different events, ETC overload and partial ETC inhibition, promote superoxide-dependent tumor cell migration, invasion, clonogenicity, and metastasis, and specific scavenging of mitochondrial superoxide with mitoTEMPO blocked tumor cell Migration and prevented spontaneous tumor metastasis in murine and human tumor models.
Journal ArticleDOI
Targeting the lactate transporter MCT1 in endothelial cells inhibits lactate-induced HIF-1 activation and tumor angiogenesis.
Pierre Sonveaux,Pierre Sonveaux,Tamara Copetti,Christophe De Saedeleer,Frédérique Végran,Julien Verrax,Kelly M. Kennedy,Eui Jung Moon,Suveera Dhup,Pierre Danhier,Françoise Frérart,Bernard Gallez,Anthony T. Ribeiro,Carine Michiels,Mark W. Dewhirst,Olivier Feron +15 more
TL;DR: This study finds that blockade of lactate influx into ECs led to inhibition of HIF-1-dependent angiogenesis and identifies MCT1 inhibition as a therapeutic modality combining antimetabolic and anti-angiogenic activities.
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Anticancer Targets in the Glycolytic Metabolism of Tumors: A Comprehensive Review
TL;DR: This review addresses in a comprehensive manner the main molecular events accounting for high-rate glycolysis in cancer, and highlights the key role exerted by the hypoxia-inducible transcription factor HIF-1 in long-term adaptation to Hypoxia.
Journal ArticleDOI
p65/RelA Modulates BECN1 Transcription and Autophagy∇†
Tamara Copetti,Cosetta Bertoli,Emiliano Dalla,Francesca Demarchi,Claudio Schneider,Claudio Schneider +5 more
TL;DR: Data suggest that autophagy could represent a novel route modulated by p65 to regulate cell survival and control T-cell homeostasis.
Journal ArticleDOI
Lactate activates HIF-1 in oxidative but not in Warburg-phenotype human tumor cells
Christophe De Saedeleer,Tamara Copetti,Paolo E. Porporato,Julien Verrax,Olivier Feron,Pierre Sonveaux +5 more
TL;DR: Lactate activates HIF-1 and triggers tumor angiogenesis and tumor growth in vivo, an activity that is found to be under the specific upstream control of the lactate transporter monocarboxylate transporter 1 (MCT1) expressed in tumor cells.