T
Tamás Beke-Somfai
Researcher at Hungarian Academy of Sciences
Publications - 64
Citations - 1192
Tamás Beke-Somfai is an academic researcher from Hungarian Academy of Sciences. The author has contributed to research in topics: Membrane & Circular dichroism. The author has an hindex of 15, co-authored 57 publications receiving 874 citations. Previous affiliations of Tamás Beke-Somfai include Chalmers University of Technology & Eötvös Loránd University.
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Probing Microscopic Orientation in Membranes by Linear Dichroism.
TL;DR: While the macroscopic orientation of a liquid-phase bilayer decreases with increasing cholesterol concentration, the local orientation is improved and pyrene is found to be sensitive to the local effects induced by cholesterol and temperature on the bilayer.
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Protein-Ligand Interaction Energy-Based Entropy Calculations: Fundamental Challenges For Flexible Systems.
Gergely Kohut,Adam Liwo,Szilvia Bősze,Tamás Beke-Somfai,Tamás Beke-Somfai,Sergey A. Samsonov +5 more
TL;DR: The results demonstrated that the IE method is intended for calculating entropy change for binding partners in fixed conformations, as by the original definition of IE, and is not applicable to the molecular complexes in which the interacting partners undergo significant conformational changes during the binding process.
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Heparin and Heparan Sulfate Binding of the Antiparasitic Drug Imidocarb: Circular Dichroism Spectroscopy, Isothermal Titration Calorimetry, and Computational Studies
TL;DR: In this article, the binding interaction between IMD and GAGs was assessed by using an exciton-type circular dichroism (CD) spectroscopic features measured at low salt concentration.
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The lipid mediator lysophosphatidic acid induces folding of disordered peptides with basic amphipathic character into rare conformations
TL;DR: It is proposed that accumulation of LPA in signalling or pathological processes might modulate host-defense activity or trigger certain processes by direct interaction with cationic amphipathic peptide sequences.
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Chiral 1,5-disubstituted 1,2,3-triazoles - versatile tools for foldamers and peptidomimetic applications.
Anna Said Stålsmeden,Andrew J. Paterson,Imola Cs. Szigyártó,Linda Thunberg,Johan Johansson,Tamás Beke-Somfai,Nina Kann +6 more
TL;DR: The synthesis of all eight possible chiral derivatives of a triazole monomer prepared via a ruthenium-catalyzed azide alkyne cycloaddition (RuAAC) is presented, indicating their capacity to form several low energy conformers.