T
Tamás F. Freund
Researcher at Hungarian Academy of Sciences
Publications - 5
Citations - 5733
Tamás F. Freund is an academic researcher from Hungarian Academy of Sciences. The author has contributed to research in topics: Inhibitory postsynaptic potential & Glutamatergic. The author has an hindex of 5, co-authored 5 publications receiving 5472 citations.
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Journal ArticleDOI
Brain monoglyceride lipase participating in endocannabinoid inactivation
Thien P. Dinh,D. Carpenter,Frances M. Leslie,Tamás F. Freund,István Katona,Stefano L. Sensi,Satish Kathuria,Daniele Piomelli +7 more
TL;DR: The results suggest that hydrolysis by means of MGL is a primary mechanism for 2-AG inactivation in intact neurons, and not on the accumulation of anandamide, another endocannabinoid lipid.
Journal ArticleDOI
Cannabinoids inhibit hippocampal GABAergic transmission and network oscillations.
Norbert Hájos,István Katona,S S Naiem,Ken Mackie,Catherine Ledent,Istvan Mody,Tamás F. Freund +6 more
TL;DR: It is concluded that activation of presynaptic CB1 receptors decreases Ca2+‐dependent GABA release, and thereby reduces the power of hippocampal network oscillations.
Journal ArticleDOI
Molecular Composition of the Endocannabinoid System at Glutamatergic Synapses
István Katona,Gabriella M. Urbán,Matthew Wallace,Catherine Ledent,Kwang-Mook Jung,Daniele Piomelli,Ken Mackie,Tamás F. Freund +7 more
TL;DR: It is shown, by using two independent riboprobes, that principal cell populations of the hippocampus express high levels of diacylglycerol lipase α (DGL-α), the enzyme involved in generation of the endocannabinoid 2-arachidonoyl- glycerol (2-AG), which may contribute to homosynaptic plasticity of excitatory synapses and to heterosynptic plasticity between excitatories and inhibitory contacts.
Journal ArticleDOI
Excitement Reduces Inhibition via Endocannabinoids
Tamás F. Freund,Norbert Hájos +1 more
TL;DR: This issue of Neuron provides evidence for another form of endocannabinoid-mediated depression of hippocampal inhibition, which is activity dependent and long lasting.