Excitement Reduces Inhibition via Endocannabinoids
Tamás F. Freund,Norbert Hájos +1 more
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TLDR
This issue of Neuron provides evidence for another form of endocannabinoid-mediated depression of hippocampal inhibition, which is activity dependent and long lasting.About:
This article is published in Neuron.The article was published on 2003-05-08 and is currently open access. It has received 39 citations till now. The article focuses on the topics: Synaptic signaling.read more
Citations
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Journal ArticleDOI
The endocannabinoid system in brain reward processes
TL;DR: The influence of the endocannabinoid system on brain reward processes may depend on the degree of activation of the different brain areas involved and might represent a mechanism for fine‐tuning dopaminergic activity.
Journal ArticleDOI
Sleep and movement differentiates actions of two types of somatostatin-expressing GABAergic interneuron in rat hippocampus.
Linda Katona,Damien Lapray,Tim J. Viney,Abderrahim Oulhaj,Zsolt Borhegyi,Benjamin R. Micklem,Thomas Klausberger,Thomas Klausberger,Peter Somogyi,Peter Somogyi +9 more
TL;DR: It is shown that behavioral and network states differentiate the activities of bistratified and O-LM cells in freely moving rats, and peptide/GABA-releasing interneurons' firing patterns during behavior are unknown.
Journal ArticleDOI
Pharmacological treatments that facilitate extinction of fear: relevance to psychotherapy.
TL;DR: It is concluded that extinction is an excellent model system for the study of fear inhibition and an indispensable tool for the screening of putative pharmacotherapies for clinical use.
Journal ArticleDOI
Differential diurnal variations of anandamide and 2-arachidonoyl-glycerol levels in rat brain.
M. Valenti,Daniela Viganò,M. G. Casico,Tiziana Rubino,Luca Steardo,Daniela Parolaro,V. Di Marzo +6 more
TL;DR: The levels of the two major endocannabinoids, anandamide and 2-arachidonoyl-glycerol (2-AG), in four areas of the rat brain, change dramatically between the light and dark phases of the day, suggesting that the levels might be under the control of endogenous factors known to undergo diurnal variations.
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A therapeutic role for cannabinoid CB1 receptor antagonists in major depressive disorders.
TL;DR: Cannabinoid receptors in the CNS have been implicated in the control of appetite, cognition, mood and drug dependence and CB1 receptor antagonism might constitute an integrated pharmacotherapeutic approach that impacts the affective, cognitive, appetitive and motivational neuronal networks involved in mood disorders.
References
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The endogenous cannabinoid system controls extinction of aversive memories
Giovanni Marsicano,Carsten T. Wotjak,Shahnaz Christina Azad,Shahnaz Christina Azad,Tiziana Bisogno,Gerhard Rammes,Maria Grazia Cascio,Heike Hermann,Jianrong Tang,Clementine Hofmann,Walter Zieglgänsberger,Vincenzo Di Marzo,Beat Lutz +12 more
TL;DR: Treatment of wild-type mice with the CB1 antagonist SR141716A mimicked the phenotype of CB1-deficient mice, revealing that CB1 is required at the moment of memory extinction, and proposes that endocannabinoids facilitate extinction of aversive memories through their selective inhibitory effects on local inhibitory networks in the amygdala.
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Endogenous cannabinoids mediate retrograde signalling at hippocampal synapses.
Rachel Wilson,Roger A. Nicoll +1 more
TL;DR: The transient suppression of GABA-mediated transmission that follows depolarization of hippocampal pyramidal neurons is mediated by retrograde signalling through release of endogenous cannabinoids, indicating that the function of endogenous cannabinoid released by depolarized hippocampal neurons might be to downregulate GABA release.
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Presynaptically Located CB1 Cannabinoid Receptors Regulate GABA Release from Axon Terminals of Specific Hippocampal Interneurons
István Katona,Beáta Sperlágh,Attila Sik,Attila Käfalvi,E. Sylvester Vizi,Ken Mackie,Tamás F. Freund +6 more
TL;DR: The results suggest that cannabinoid-mediated modulation of hippocampal interneuron networks operate largely via presynaptic receptors on CCK-immunoreactive basket cell terminals, the likely mechanism by which both endogenous and exogenous CB1 ligands interfere with hippocampal network oscillations and associated cognitive functions.
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Total number and distribution of inhibitory and excitatory synapses on hippocampal CA1 pyramidal cells
TL;DR: The results indicate that the highly convergent excitation arriving onto the distal dendrites of pyramidal cells is primarily controlled by proximally located inhibition and the organization of excitatory and inhibitory inputs in layers receiving Schaffer collateral input (radiatum/oriens) versus perforant path input (lacunosum-moleculare) is significantly different.
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Retrograde Inhibition of Presynaptic Calcium Influx by Endogenous Cannabinoids at Excitatory Synapses onto Purkinje Cells
TL;DR: It is suggested that Purkinje cells release endogenous cannabinoids in response to elevated calcium, thereby inhibiting presynaptic calcium entry and suppressing transmitter release, and suggesting a widespread role for endogenous cannabinoid in retrograde synaptic inhibition.