T
Tania L. Roth
Researcher at University of Delaware
Publications - 84
Citations - 6434
Tania L. Roth is an academic researcher from University of Delaware. The author has contributed to research in topics: Epigenetics & DNA methylation. The author has an hindex of 34, co-authored 79 publications receiving 5883 citations. Previous affiliations of Tania L. Roth include University of Alabama at Birmingham & University of Oklahoma.
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Journal ArticleDOI
Lasting epigenetic influence of early-life adversity on the BDNF gene.
TL;DR: An epigenetic molecular mechanism potentially underlying lifelong and transgenerational perpetuation of changes in gene expression and behavior incited by early abuse and neglect is highlighted.
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Epigenetic Regulation of bdnf Gene Transcription in the Consolidation of Fear Memory
TL;DR: Results suggest epigenetic modification of the bdnf gene as a mechanism for isoform-specific gene readout during memory consolidation in the hippocampus suggests selective changes in gene expression are required for long-term memory formation.
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Evidence That DNA (Cytosine-5) Methyltransferase Regulates Synaptic Plasticity in the Hippocampus
Jonathan M. Levenson,Tania L. Roth,Farah D. Lubin,Courtney A. Miller,I-Chia Huang,Priyanka Desai,Lauren M. Malone,J. David Sweatt +7 more
TL;DR: In this article, the role of DNA methyltransferase (DNMT) activity in regulating the induction of synaptic plasticity was examined and it was found that the DNA within promoters for reelin and brain-derived neurotrophic factor exhibited rapid and dramatic changes in cytosine methylation when DNMT activity was inhibited.
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Epigenetic modification of hippocampal Bdnf DNA in adult rats in an animal model of post-traumatic stress disorder
TL;DR: Evidence is provided that traumatic stress occurring in adulthood can induce CNS gene methylation, and the hypothesis that epigenetic marking of the Bdnf gene may underlie hippocampal dysfunction in response to traumatic stress is supported.
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Chronic early life stress induced by limited bedding and nesting (LBN) material in rodents: critical considerations of methodology, outcomes and translational potential
Claire-Dominique Walker,Kevin G. Bath,Marian Joëls,Aniko Korosi,Muriel H. Larauche,Paul J. Lucassen,Margaret J. Morris,Charlis Raineki,Tania L. Roth,Regina M. Sullivan,Yvette Taché,Tallie Z. Baram +11 more
TL;DR: The immediate and long-term effects of exposure to early life stress (ELS) have been documented in humans and animal models as discussed by the authors, with models that produce altered maternal behavior ranging from fragmentation of care to maltreatment of infants.