T
Tao Chen
Researcher at Fourth Military Medical University
Publications - 128
Citations - 11519
Tao Chen is an academic researcher from Fourth Military Medical University. The author has contributed to research in topics: Long-term potentiation & Excitatory postsynaptic potential. The author has an hindex of 36, co-authored 111 publications receiving 8564 citations. Previous affiliations of Tao Chen include Xi'an Jiaotong University & UPRRP College of Natural Sciences.
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Journal ArticleDOI
An Increase in Synaptic NMDA Receptors in the Insular Cortex Contributes to Neuropathic Pain
Shuang Qiu,Tao Chen,Kohei Koga,Yan-yan Guo,Yan-yan Guo,Hui Xu,Hui Xu,Qian Song,Jie-jie Wang,Giannina Descalzi,Bong-Kiun Kaang,Jianhong Luo,Min Zhuo,Min Zhuo,Min Zhuo,Ming-gao Zhao,Ming-gao Zhao +16 more
TL;DR: It is found that in a mouse model in which peripheral nerve injury leads to the development of neuropathic pain, the insular cortex showed changes in synaptic plasticity, which were associated with a long-term increase in the amount of synaptic N-methyl-d-aspartate receptors, but not that of extrasynaptic NMDARs.
Journal ArticleDOI
Neuronal and microglial mechanisms for neuropathic pain in the spinal dorsal horn and anterior cingulate cortex.
TL;DR: Understanding a possible connection between the SDH and ACC, including a neuron–microglia interaction, may provide insights into the mechanisms used to amplify pain signals related to neuropathic pain and clues to aid the development of new therapeutic agents for the management of chronic pain.
Journal ArticleDOI
Sirt3 confers protection against neuronal ischemia by inducing autophagy: Involvement of the AMPK-mTOR pathway.
Shuhui Dai,Tao Chen,Xia Li,Kangyi Yue,Peng Luo,Yang Likun,Jie Zhu,Wang Yuhai,Zhou Fei,Xiaofan Jiang +9 more
TL;DR: Findings demonstrate that Sirt3 protects against OGD insult by inducing autophagy through regulation of the AMPK‐mTOR pathway and that Sirts3 may have therapeutic value for protecting neurons from cerebral ischemia.
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Sirt1-Sirt3 axis regulates human blood-brain barrier permeability in response to ischemia.
TL;DR: Findings demonstrate that the Sirt1-Sirt3 axis might act as an important modulator in BBB physiology, and could be a therapeutic target for ischemic stroke via regulating mitochondrial ROS generation.
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Sirt3 Protects Cortical Neurons against Oxidative Stress via Regulating Mitochondrial Ca2+ and Mitochondrial Biogenesis
TL;DR: Results suggest that Sirt3 acts as a prosurvival factor playing an essential role to protect cortical neurons under H2O2 induced oxidative stress, possibly through regulating mitochondrial Ca2+ homeostasis and mitochondrial biogenesis.