T
Tariq Daouda
Researcher at Université de Montréal
Publications - 18
Citations - 582
Tariq Daouda is an academic researcher from Université de Montréal. The author has contributed to research in topics: MHC class I & Proteogenomics. The author has an hindex of 7, co-authored 17 publications receiving 461 citations. Previous affiliations of Tariq Daouda include Broad Institute.
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Journal ArticleDOI
Global proteogenomic analysis of human MHC class I-associated peptides derived from non-canonical reading frames.
Céline M. Laumont,Tariq Daouda,Jean-Philippe Laverdure,Eric Bonneil,Olivier Caron-Lizotte,Marie-Pierre Hardy,Diana Paola Granados,Chantal Durette,Sébastien Lemieux,Pierre Thibault,Claude Perreault,Claude Perreault +11 more
TL;DR: Proteogenomic analyses of MAPs eluted from human B cells are performed using high-throughput mass spectrometry to probe the six-frame translation of the B-cell transcriptome and report that ∼10% ofMAPs originate from allegedly noncoding genomic sequences or exonic out-of- frame translation.
Journal ArticleDOI
MHC class I–associated peptides derive from selective regions of the human genome
Hillary Pearson,Tariq Daouda,Diana Paola Granados,Chantal Durette,Eric Bonneil,Mathieu Courcelles,Anja Rodenbrock,Jean-Philippe Laverdure,Caroline Côté,Sylvie Mader,Sébastien Lemieux,Pierre Thibault,Claude Perreault +12 more
TL;DR: The results show preferential selection of MAPs from a limited repertoire of proteins with distinctive features from the MHC class I immunopeptidome, which has profound implications in autoimmunity and cancer immunology.
Journal ArticleDOI
Impact of genomic polymorphisms on the repertoire of human MHC class I-associated peptides
Diana Paola Granados,Dev Sriranganadane,Tariq Daouda,Antoine Zieger,Céline M. Laumont,Olivier Caron-Lizotte,Geneviève Boucher,Marie-Pierre Hardy,Patrick Gendron,Caroline Côté,Sébastien Lemieux,Pierre Thibault,Claude Perreault +12 more
TL;DR: The method provides fundamental insights into the relationship between the genomic self and the immune self and accelerates the discovery of polymorphic MIPs (also known as minor histocompatibility antigens), which play a major role in allorecognition.
Journal ArticleDOI
MHC I-associated peptides preferentially derive from transcripts bearing miRNA response elements
Diana Paola Granados,Wafaa Yahyaoui,Céline M. Laumont,Tariq Daouda,Tara L. Muratore-Schroeder,Caroline Côté,Jean-Philippe Laverdure,Sébastien Lemieux,Pierre Thibault,Claude Perreault +9 more
TL;DR: The data support an emerging model in which the generation of MIPs by a transcript depends on its abundance and DRiP rate, which is regulated to a large extent by miRNAs.
Journal ArticleDOI
Detection of Quiescent Radioresistant Epithelial Progenitors in the Adult Thymus.
Maude Dumont-Lagacé,Hervé Gerbe,Tariq Daouda,Jean-Philippe Laverdure,Sylvie Brochu,Sébastien Lemieux,Etienne Gagnon,Claude Perreault +7 more
TL;DR: The ability of UEA1– quiescent TECs to participate to TEC regeneration qualifies them as in vivo progenitor cells particularly relevant in the context of regeneration following acute thymic injury.