Tatiana Simon-Ebert

TL;DR: This protocol of astroglia-to-neuron conversion by a single neurogenic transcription factor provides a stringent experimental system to study the specification of a selective neuronal subtype, thus offering an alternative to the use of embryonic or neural stem cells.

TL;DR: A culture preparation of the adult mouse subependymal zone (SEZ) is described, which allows for continuous single-cell tracking of aNSC behavior and provides an experimental system for studying instructive or permissive effects of signal molecules on aN SC modes of cell division and lineage progression.

TL;DR: In this article, single-cell RNA-seq revealed 7 gene expression clusters of astrocytes, with 4 forming a supercluster. All clusters showed expression of proliferation-related genes, and proliferation of diencephalic astrocell was confirmed by immunostaining.

TL;DR: In this article, the authors examined the transcriptome induced by the proneural factors Ascl1 and Neurog2 in spinal cord-derived astrocytes in vitro.

TL;DR: In this article , the authors combined spatial and single-cell transcriptomics to chart the transcriptomic signature of the injured murine cerebral cortex, and identified specific states of astrocytes, microglia, and oligodendrocyte precursor cells contributing to this signature.