Tatsuo Shioda

TL;DR: Functional analyses of RantES promoter activity indicated that the RANTES-28G mutation increases RANTes expression in HIV-1-infected individuals and thus delays the progression of the HIV- 1 disease.

TL;DR: This work sequenced the region containing the 5' proximal half of the F gene, and the subsequent HN and L genes, and predicted the complete amino acid sequence of the products of these genes, confirming that all the genes are flanked by consensus sequences and suggest that the viral mRNAs are capable of forming stem-and-loop structures.

TL;DR: Determination of amino acid compositions of viral proteins, P, HN, Fo, NP, NP and M, led us to conclude that NP and P are the gene products of OP-1 and OP-2, respectively.

TL;DR: In this paper, a series of anti-spike monoclonal antibodies from coronavirus disease 2019 (COVID-19) patients were screened and found that some of the antibodies against the N-terminal domain induced the open conformation of RBD and thus enhanced the binding capacity of the spike protein to ACE2 and infectivity of SARS-CoV-2.

TL;DR: An intermolecular fluorescence resonance energy transfer-based HIV-1-expression assay is developed employing cyan and yellow fluorescent protein-tagged protease monomers and identified non-peptidyl small molecule inhibitors of protease dimerization.