T
Tatsuo Suga
Researcher at Gunma University
Publications - 51
Citations - 7449
Tatsuo Suga is an academic researcher from Gunma University. The author has contributed to research in topics: Klotho & Lung cancer. The author has an hindex of 18, co-authored 51 publications receiving 6998 citations. Previous affiliations of Tatsuo Suga include University of Texas Southwestern Medical Center.
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Journal ArticleDOI
Mutation of the mouse klotho gene leads to a syndrome resembling ageing
Makoto Kuro-o,Matsumura Yutaka,Hiroki Aizawa,Hiroshi Kawaguchi,Tatsuo Suga,Toshihiro Utsugi,Yoshio Ohyama,Masahiko Kurabayashi,Tadashi Kaname,Eisuke Kume,Hitoshi Iwasaki,Akihiro Iida,Takako Shiraki-Iida,Satoshi Nishikawa,Ryozo Nagai,Ryozo Nagai,Yo-ichi Nabeshima +16 more
TL;DR: A new gene, termed klotho, has been identified that is involved in the suppression of several ageing phenotypes in the mouse, and may function as part of a signalling pathway that regulates ageing in vivo and morbidity in age-related diseases.
Mutation of the mouse klotho gene leads to a syndrome resembling ageing
Makoto Kuro-o,Matsumura Yutaka,H. Arawa,Hiroshi Kawaguchi,Tatsuo Suga,Toshihiro Utsugi,Yoshio Ohyama,Masahiko Kurabayashi,Tadashi Kaname,Eisuke Kume,H. Iwasaki,Akihiro Iida,Takako Shiraki-Iida,Satoshi Nishikawa,Ryozo Nagai,Yo-ichi Nabeshima,K. Sharma,L. Kelly,T. Dandekar +18 more
TL;DR: A new gene, termed klotho, has been identified that is involved in the suppression of several ageing phenotypes in the mouse, including short lifespan, infertility, arteriosclerosis, skin atrophy, osteoporosis and emphysema as mentioned in this paper.
Journal ArticleDOI
Klotho protein protects against endothelial dysfunction.
Yuichiro Saito,Takahiro Yamagishi,Tetsuya Nakamura,Yoshio Ohyama,Hiroki Aizawa,Tatsuo Suga,Matsumura Yutaka,Hiroaki Masuda,Masahiko Kurabayashi,Makoto Kuro-o,Yo-ichi Nabeshima,Ryozo Nagai +11 more
TL;DR: It is concluded that the klotho protein protects the cardiovascular system through endothelium-derived NO production by humoral pathways.
Journal ArticleDOI
Disruption of the klotho gene causes pulmonary emphysema in mice. Defect in maintenance of pulmonary integrity during postnatal life.
Tatsuo Suga,Masahiko Kurabayashi,Yoshichika Sando,Yoshio Ohyama,Toshitaka Maeno,Yuri Maeno,Hiroki Aizawa,Matsumura Yutaka,Tomoyuki Kuwaki,Makoto Kuro-o,Yo-ichi Nabeshima,Ryozo Nagai +11 more
TL;DR: It is indicated that klotho gene expression is essential to maintaining pulmonary integrity during postnatal life and the relationship between aging and pulmonary emphysema in humans both histologically and functionally.
Journal ArticleDOI
Endothelial dysfunction in the klotho mouse and downregulation of klotho gene expression in various animal models of vascular and metabolic diseases.
Ryozo Nagai,Y. Saito,Yoshio Ohyama,Hiroki Aizawa,Tatsuo Suga,Tetsuya Nakamura,Masahiko Kurabayashi,Makoto Kuro-o +7 more
TL;DR: Whether the Klotho protein is a humoral factor protecting against endothelial dysfunction and whether klotho mRNA expression in rat kidney is altered under pathological conditions such as hypertension, hyperlipidemia, renal failure, and inflammatory stress is examined.