Tennille Sibbritt

TL;DR: The widespread presence of modified cytosines throughout coding and non-coding sequences in a transcriptome is demonstrated, suggesting a broader role of this modification in the post-transcriptional control of cellular RNA function.

TL;DR: Transcriptome-wide quantitative mapping of 5-methylcytosine in Arabidopsis via RNA bisulfite sequencing reveals crucial links between this modification and cell division and plant stress pathways and provides insights into the targeting mechanism of TRM4B by demonstrating that a 50-nucleotide sequence flanking m5C C3349 in MAIGO5 mRNA is sufficient to confer methylation of a transgene reporter in Nicotiana benthamiana.

TL;DR: Although overall activated in OSCC, miR-200/miR-205 suppression in oral CSCs indicate that cell specific silencing of these miRNAs may drive tumor expansion and progression, and are suggested as promising candidates for future investigations.

TL;DR: It is suggested that miR-205 is an epigenetically regulated tumor suppressor that targets MED1 and may provide a potential biomarker in prostate cancer management.

TL;DR: It is shown that detecting changes in primary miRNA transcription levels is a valuable method for detection of local epigenetic modifications that are associated with changes in mature miRNA expression.