T
Teresa Gomez-Isla
Researcher at Harvard University
Publications - 110
Citations - 15851
Teresa Gomez-Isla is an academic researcher from Harvard University. The author has contributed to research in topics: Alzheimer's disease & Dementia. The author has an hindex of 55, co-authored 104 publications receiving 14181 citations. Previous affiliations of Teresa Gomez-Isla include Massachusetts Institute of Technology & Autonomous University of Barcelona.
Papers
More filters
Journal ArticleDOI
Profound Loss of Layer II Entorhinal Cortex Neurons Occurs in Very Mild Alzheimer’s Disease
Teresa Gomez-Isla,Joseph L. Price,Daniel W. McKeel,John C. Morris,John H. Growdon,Bradley T. Hyman +5 more
TL;DR: Stereological principles of neuron counting support the conclusion that a marked decrement of layer II neurons distinguishes even very mild AD from nondemented aging.
Journal ArticleDOI
Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer's disease.
Teresa Gomez-Isla,Richard D. Hollister,H. L. West,Stina Mui,John H. Growdon,Ronald C. Petersen,Joseph E. Parisi,Bradley T. Hyman +7 more
TL;DR: It is suggested that neuronal loss in association areas such as the superior temporal sulcus contributes directly to cognitive impairment in AD.
Journal ArticleDOI
Tau positron emission tomographic imaging in aging and early Alzheimer disease
Keith A. Johnson,Aaron P. Schultz,Rebecca A. Betensky,J. Alex Becker,Jorge Sepulcre,Dorene M. Rentz,Dorene M. Rentz,Elizabeth C. Mormino,Jasmeer P. Chhatwal,Jasmeer P. Chhatwal,Rebecca E. Amariglio,Rebecca E. Amariglio,Kate V. Papp,Kate V. Papp,Gad A. Marshall,Gad A. Marshall,Mark W. Albers,Samantha Mauro,Lesley C. Pepin,Jonathan Alverio,Kelly Judge,Marlie Philiossaint,Timothy M. Shoup,Daniel Yokell,Bradford C. Dickerson,Teresa Gomez-Isla,Bradley T. Hyman,Neil Vasdev,Reisa A. Sperling +28 more
TL;DR: Detection of focal brain tau deposition during life could greatly facilitate accurate diagnosis of Alzheimer disease (AD), staging and monitoring of disease progression, and development of disease‐modifying therapies.
Journal ArticleDOI
Endocytic Pathway Abnormalities Precede Amyloid β Deposition in Sporadic Alzheimer’s Disease and Down Syndrome : Differential Effects of APOE Genotype and Presenilin Mutations
Anne M. Cataldo,Corrinne M. Peterhoff,Juan C. Troncoso,Teresa Gomez-Isla,Bradley T. Hyman,Ralph A. Nixon +5 more
TL;DR: Early endosomal abnormalities provide a mechanistic link between EP alterations, genetic susceptibility factors, and Abeta generation and suggest differences that may be involved in Abetageneration and beta amyloidogenesis in subtypes of AD.
Journal ArticleDOI
Use of structural magnetic resonance imaging to predict who will get Alzheimer's disease.
Ronald J. Killiany,Teresa Gomez-Isla,Mark B. Moss,Ron Kikinis,Tamas Sandor,Ferenc A. Jolesz,Rudolph E. Tanzi,Kenneth J. Jones,Bradley T. Hyman,Marilyn S. Albert +9 more
TL;DR: Baseline MRI measures of the entorhinal cortex, the banks of the superior temporal sulcus, and the anterior cingulate were most useful in discriminating the status of the subjects on follow‐up examination and provided information concerning the hierarchical fashion in which the pathology of AD may affect the brain during its prodromal phase.