T
Tess A. Stanly
Researcher at University of York
Publications - 9
Citations - 309
Tess A. Stanly is an academic researcher from University of York. The author has contributed to research in topics: Receptor & Beta-defensin 2. The author has an hindex of 6, co-authored 9 publications receiving 215 citations. Previous affiliations of Tess A. Stanly include Newcastle University & University of Oxford.
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Journal ArticleDOI
Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations
Stephan Wilmes,Stephan Wilmes,Maximillian Hafer,Joni Vuorio,Julie A. Tucker,Hauke Winkelmann,Sara Löchte,Tess A. Stanly,Katiuska Pulgar Prieto,Chetan Poojari,Vivek Sharma,Christian Richter,Rainer Kurre,Stevan R. Hubbard,K. Christopher Garcia,Ignacio Moraga,Ilpo Vattulainen,Ian S. Hitchcock,Jacob Piehler +18 more
TL;DR: Atomic modeling and molecular dynamics simulations based on a detailed energetic analysis of the interactions involved in dimerization yielded a mechanistic blueprint for homodimeric class I cytokine receptor activation and its dysregulation by individual mutations.
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A comparative study on fluorescent cholesterol analogs as versatile cellular reporters
Erdinc Sezgin,Fatma Betul Can,Falk Schneider,Mathias P. Clausen,Mathias P. Clausen,Silvia Galiani,Tess A. Stanly,Dominic Waithe,Alexandria Colaco,Alf Honigmann,Daniel Wüstner,Frances M. Platt,Christian Eggeling +12 more
TL;DR: Different fluorescent lipid analogs are compared for their performance in cellular assays and their applicability in fluorescence correlation spectroscopy (FCS)-based and super-resolution stimulated emission depletion-FCS-based measurements of membrane diffusion dynamics.
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Toll-like receptor-mediated, enhanced production of profibrotic TIMP-1 in monocytes from patients with systemic sclerosis: role of serum factors
Marzena Ciechomska,CA Huigens,Thomas Hügle,Tess A. Stanly,A Gessner,Bridget Griffiths,Timothy R D J Radstake,Sophie Hambleton,Steven O'Reilly,Jacob M van Laar +9 more
TL;DR: This study demonstrates profibrotic properties of circulating monocytes from patients with SSc and a key role for TLR signalling, particularly TLR8, in TIMP-1 secretion and matrix remodelling.
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Critical importance of appropriate fixation conditions for faithful imaging of receptor microclusters.
Tess A. Stanly,Marco Fritzsche,Suneale Banerji,Esther García,Jorge Bernardino de la Serna,David A. Jackson,Christian Eggeling +6 more
TL;DR: This study highlights how inadequate fixation can lead to the formation of artefactual clustering of receptors in lymphatic endothelial cells, and provides fixation conditions for studying membrane receptor organisation.
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The cortical actin network regulates avidity-dependent binding of hyaluronan by the lymphatic vessel endothelial receptor LYVE-1.
Tess A. Stanly,Tess A. Stanly,Marco Fritzsche,Suneale Banerji,Dilip Shrestha,Falk Schneider,Christian Eggeling,David A. Jackson +7 more
TL;DR: An actin-mediated constraint on LYVE-1 clustering in lymphatic endothelium that tunes the receptor for selective engagement with hyaluronan assemblages in the glycocalyx that are large enough to cross-bridge the corral-bound LYve-1 molecules and thereby facilitate leukocyte adhesion and transmigration is pointed to.