T
Tetsuro Yoshimaru
Researcher at University of Tokushima
Publications - 53
Citations - 1522
Tetsuro Yoshimaru is an academic researcher from University of Tokushima. The author has contributed to research in topics: Mast cell & Degranulation. The author has an hindex of 23, co-authored 52 publications receiving 1357 citations. Previous affiliations of Tetsuro Yoshimaru include Nihon University.
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Journal ArticleDOI
Fc epsilon RI signaling of mast cells activates intracellular production of hydrogen peroxide: role in the regulation of calcium signals.
Yoshihiro Suzuki,Tetsuro Yoshimaru,Takashi Matsui,Toshio Inoue,Osamu Niide,Satoshi Nunomura,Chisei Ra +6 more
TL;DR: It is shown that in both the RBL-2H3 mast cell line and bone marrow-derived mast cells, FcεRI cross-linking stimulates intracellular oxidative burst, including hydrogen peroxide (H2O2) production, as defined with the oxidant-sensitive dyes dichlorofluorescein and scopoletin and the selective scavenger ebselen.
Journal ArticleDOI
Molecular features of triple negative breast cancer cells by genome-wide gene expression profiling analysis.
Masato Komatsu,Tetsuro Yoshimaru,Taisuke Matsuo,Kazuma Kiyotani,Yasuo Miyoshi,Toshihito Tanahashi,Kazuhito Rokutan,Rui Yamaguchi,Ayumu Saito,Seiya Imoto,Satoru Miyano,Yusuke Nakamura,Mitsunori Sasa,Mitsuo Shimada,Toyomasa Katagiri +14 more
TL;DR: To clarify the molecular mechanisms involved in the carcinogenesis of TNBC and to identify target molecules for novel anticancer drugs, gene expression profiles of 30 TNBCs as well as 13 normal epithelial ductal cells that were purified by laser-microbeam microdissection are analyzed.
Book ChapterDOI
Role of Oxidants in Mast Cell Activation
TL;DR: This review summarizes current knowledge on the role of endogenous oxidants in mast cell activation and defines particular biochemical pathways that can be targeted by ROS and/or cellular redox balance.
Journal ArticleDOI
Blockade of superoxide generation prevents high-affinity immunoglobulin E receptor-mediated release of allergic mediators by rat mast cell line and human basophils
Tetsuro Yoshimaru,Yoshihiro Suzuki,Takashi Matsui,Kohei Yamashita,T. Ochiai,Mitsuo Yamaki,Kazufumi Shimizu +6 more
TL;DR: This work has shown that rat peritoneal mast cells and mast cell model rat basophilic leukaemia cells generate intracellular reactive oxygen species (ROS) in response to antigen challenge, and the physiological significance of the burst of ROS is poorly understood.
Journal ArticleDOI
Dapsone suppresses human neutrophil superoxide production and elastase release in a calcium-dependent manner.
T. Suda,Yoshihiro Suzuki,Takashi Matsui,Toshio Inoue,Osamu Niide,Tetsuro Yoshimaru,H. Suzuki,Chisei Ra,T. Ochiai +8 more
TL;DR: The drug has an outstanding therapeutic efficacy against many skin diseases characterized by neutrophil‐rich infiltrates; however, mechanisms of its action are poorly understood.