Rui Yamaguchi

TL;DR: The flagship paper of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium describes the generation of the integrative analyses of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types, the structures for international data sharing and standardized analyses, and the main scientific findings from across the consortium studies.

TL;DR: An extensive genome-wide expression profiling of 226 primary human stage I-II lung adenocarcinomas helps identify patients who may gain the most benefit from adjuvant chemotherapy after surgical resection and further stratify more or less aggressive subgroups of triple-negative lung ADC.

TL;DR: The proposed SVAR method is able to model gene regulatory networks in frequent situations in which the number of samples is lower than thenumber of genes, making it possible to naturally infer partial Granger causalities without any a priori information.

TL;DR: In this article, the authors identified glutaminase 1 (GLS1) as an essential gene for the survival of human senescent cells and showed that inhibition of GLS1-dependent glutaminolysis in aged mice eliminated the cells specifically and ameliorated age-associated organ dysfunction.

TL;DR: Serum exosomal miR-203 expression is a novel biomarker for predicting metastasis, possibly via promoting the differentiation of monocytes to M2-TAMs in CRC patients, and the concept of site-dependent functions for mi R-203 in tumor progression is proposed.