T
Tetsuya Mitsudomi
Researcher at Kindai University
Publications - 583
Citations - 51959
Tetsuya Mitsudomi is an academic researcher from Kindai University. The author has contributed to research in topics: Lung cancer & Epidermal growth factor receptor. The author has an hindex of 97, co-authored 541 publications receiving 46183 citations. Previous affiliations of Tetsuya Mitsudomi include University of Occupational and Environmental Health Japan & Gunma University.
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Journal ArticleDOI
Efficacy of the MAGE-A3 cancer immunotherapeutic as adjuvant therapy in patients with resected MAGE-A3-positive non-small-cell lung cancer (MAGRIT): a randomised, double-blind, placebo-controlled, phase 3 trial
Johan Vansteenkiste,Byoung Chul Cho,Tonu Vanakesa,Tommaso De Pas,Marcin Zieliński,Moon Soo Kim,Jacek Jassem,Masahiro Yoshimura,Jubrail Dahabreh,Haruhiku Nakayama,Libor Havel,Haruhiko Kondo,Tetsuya Mitsudomi,Konstantinos Zarogoulidis,Oleg Gladkov,Katalin Udud,Hirohito Tada,Hans Hoffman,Anders Bugge,Paul D. Taylor,Emilio Esteban Gonzalez,Mei Lin Liao,Jianxing He,Jean-Louis Pujol,Jamila Louahed,Muriel Debois,Vincent Brichard,C. Debruyne,Patrick Therasse,Nasser K. Altorki +29 more
TL;DR: The primary endpoint was disease-free survival in the overall population, the no-chemotherapy population, and patients with a potentially predictive gene signature, which could not identify a gene signature predictive of clinical benefit to MAGE-A3 immunotherapeutic.
Journal Article
Cyclooxygenase-2 Inhibitor Induces Apoptosis and Enhances Cytotoxicity of Various Anticancer Agents in Non-Small Cell Lung Cancer Cell Lines
Toyoaki Hida,Ken Ichi Kozaki,Hideki Muramatsu,Akira Masuda,Shigeki Shimizu,Tetsuya Mitsudomi,Takahiko Sugiura,Makoto Ogawa,Takashi Takahashi +8 more
TL;DR: This study shows that a cyclooxygenase (COX)-2 inhibitor, nimesulide, can inhibit proliferation of non-small cell lung cancer cell lines in vitro in a dose-dependent manner, in part by inducing apoptosis even at clinically achievable low concentrations.
Journal Article
Prognostic significance of elevated cyclooxygenase 2 expression in primary, resected lung adenocarcinomas
Hiroyuki Achiwa,Yasushi Yatabe,Toyoaki Hida,Tetsuo Kuroishi,Ken Ichi Kozaki,Shigeo Nakamura,Makoto Ogawa,Takahiko Sugiura,Tetsuya Mitsudomi,Takashi Takahashi +9 more
TL;DR: It is suggested that an increase in COX-2 expression may be clinically significant for the prognosis of patients undergoing surgical resection of early-stage adenocarcinomas and, thus, warrant further conclusive studies involving a larger cohort.
Journal ArticleDOI
Neoadjuvant Nivolumab plus Chemotherapy in Resectable Lung Cancer.
Patrick M. Forde,Jonathan Spicer,Shun Lu,Mariano Provencio,Tetsuya Mitsudomi,Mark M. Awad,Enriqueta Felip,Stephen R. Broderick,Julie R. Brahmer,J. Swanson,Keith M. Kerr,Changli Wang,Tudor Ciuleanu,Gene Brian Saylors,Fumihiro Tanaka,Hiroyuki Ito,Keke Chen,Moishe Liberman,Everett E. Vokes,Janis M. Taube,C. Dorange,Jun Bo Cai,Joseph Fiore,Anthony Jarkowski,David Balli,Mark Sausen,Dimple Pandya,Christophe Y Calvet,Nicolas Girard +28 more
TL;DR: In patients with resectable NSCLC, neoadjuvant nivolumab plus chemotherapy resulted in significantly longer event-free survival and a higher percentage of patients with a pathological complete response than chemotherapy alone.
Journal Article
Mutations of ras genes distinguish a subset of non-small-cell lung cancer cell lines from small-cell lung cancer cell lines
TL;DR: Ras mutations play a role in the pathogenesis of a subset of NSCLC but are not involved in SCLC, and G to T or A to T transversions were the most common base substitutions occurring in codons 12 and 61 respectively.