T
Tetsuya Ohtaki
Researcher at Takeda Pharmaceutical Company
Publications - 122
Citations - 6899
Tetsuya Ohtaki is an academic researcher from Takeda Pharmaceutical Company. The author has contributed to research in topics: Receptor & Peptide. The author has an hindex of 33, co-authored 122 publications receiving 6454 citations.
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Journal ArticleDOI
Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor.
Tetsuya Ohtaki,Yasushi Shintani,Susumu Honda,Hirokazu Matsumoto,Akira Hori,Kimiko Kanehashi,Yasuko Terao,Satoshi Kumano,Yoshihiro Takatsu,Yasushi Masuda,Yoshihiro Ishibashi,Takuya Watanabe,Mari Asada,Takao Yamada,Masato Suenaga,Chieko Kitada,Satoshi Usuki,Tsutomu Kurokawa,Haruo Onda,Osamu Nishimura,Masahiko Fujino +20 more
TL;DR: It is shown that KiSS-1 encodes a carboxy-terminally amidated peptide with 54 amino-acid residues, which is isolated from human placenta as the endogenous ligand of an orphan G-protein-coupled receptor (hOT7T175) and named ‘metastin’.
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Peripheral administration of metastin induces marked gonadotropin release and ovulation in the rat
TL;DR: It is shown that subcutaneous administration of metastin increased the plasma levels of gonadotropins and induced ovulation in prepubertal female rats that had been pretreated with pregnant mare serum gonadotropic hormone to induce follicle maturation and that s.c. administered metastin induces the release of Gonadotropin via activation of the hypothalamic GnRH neurons.
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Involvement of anteroventral periventricular metastin/kisspeptin neurons in estrogen positive feedback action on luteinizing hormone release in female rats.
Sachika Adachi,Shunji Yamada,Yoshihiro Takatsu,Hisanori Matsui,Mika Kinoshita,Kenji Takase,Hitomi Sugiura,Tetsuya Ohtaki,Hirokazu Matsumoto,Yoshihisa Uenoyama,Hiroko Tsukamura,Hiroko Tsukamura,Kinji Inoue,Kei-ichiro Maeda +13 more
TL;DR: It is demonstrated that preoptic area (POA) infusion of the anti-rat metastin/kisspeptin monoclonal antibody blocked the estrogen-induced LH surge, indicating that endogenous metastIn/kissPeptin released around the POA mediates the estrogen positive feedback effect on GnRH/LH release.
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Involvement of Central Metastin in the Regulation of Preovulatory Luteinizing Hormone Surge and Estrous Cyclicity in Female Rats
Mika Kinoshita,Hiroko Tsukamura,Sachika Adachi,Hisanori Matsui,Yoshihisa Uenoyama,Kinuyo Iwata,Shunji Yamada,Kinji Inoue,Tetsuya Ohtaki,Hirokazu Matsumoto,Kei-ichiro Maeda +10 more
TL;DR: Whether metastin, the product of metastasis suppressor gene KiSS-1, is a central neuropeptide regulating GnRH/LH surge and then estrous cyclicity in the female rat is examined.
Journal ArticleDOI
Dramatic Elevation of Plasma Metastin Concentrations in Human Pregnancy: Metastin as a Novel Placenta-Derived Hormone in Humans
Yasuko Horikoshi,Hirokazu Matsumoto,Yoshihiro Takatsu,Tetsuya Ohtaki,Chieko Kitada,Satoshi Usuki,Masahiko Fujino +6 more
TL;DR: Evidence is provided for metastin as a novel placenta-derived hormone in humans and the major portion of the circulating metastin, as determined by the two-site enzyme immunoassay, represents endogenous metastin.