T
Theodore H. Lindsay
Researcher at California Institute of Technology
Publications - 21
Citations - 2485
Theodore H. Lindsay is an academic researcher from California Institute of Technology. The author has contributed to research in topics: Bone cancer & Nociception. The author has an hindex of 18, co-authored 20 publications receiving 2173 citations. Previous affiliations of Theodore H. Lindsay include University of Oregon & University of Minnesota.
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Journal ArticleDOI
Global brain dynamics embed the motor command sequence of Caenorhabditis elegans.
Saul Kato,Harris S. Kaplan,Tina Schrödel,Susanne Skora,Theodore H. Lindsay,Eviatar Yemini,Shawn R. Lockery,Manuel Zimmer +7 more
TL;DR: It is shown that the coordination of neuronal activity patterns into global brain dynamics underlies the high-level organization of behavior and serves as a robust scaffold for action selection in response to sensory input.
Journal ArticleDOI
Selective Blockade of the Capsaicin Receptor TRPV1 Attenuates Bone Cancer Pain
Joseph R. Ghilardi,Heidi Röhrich,Theodore H. Lindsay,Molly A. Sevcik,Matthew J. Schwei,Kazufumi Kubota,Kyle G. Halvorson,Jeannie Poblete,Sandra R. Chaplan,Adrienne E. Dubin,Nicholas I. Carruthers,Devin M. Swanson,Michael A. Kuskowski,Christopher M. Flores,David Julius,Patrick W. Mantyh,Patrick W. Mantyh +16 more
TL;DR: It is shown that TRPV1 is present on sensory neuron fibers that innervate the mouse femur and that, in an in vivo model of bone cancer pain, acute or chronic administration of a TRP V1 antagonist or disruption of the TRPv1 gene results in a significant attenuation of both ongoing and movement-evoked nocifensive behaviors.
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Anti-NGF therapy profoundly reduces bone cancer pain and the accompanying increase in markers of peripheral and central sensitization.
Molly A. Sevcik,Joseph R. Ghilardi,Joseph R. Ghilardi,Christopher M. Peters,Theodore H. Lindsay,Kyle G. Halvorson,Beth M. Jonas,Kazufumi Kubota,Michael A. Kuskowski,Leila Boustany,David L. Shelton,Patrick W. Mantyh,Patrick W. Mantyh +12 more
TL;DR: It is demonstrated that two administrations of a novel NGF sequestering antibody produces a profound reduction in both ongoing and movement‐evoked bone cancer pain‐related behaviors that was greater than that achieved with acute administration of 10 or 30 mg/kg of morphine.
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A blocking antibody to nerve growth factor attenuates skeletal pain induced by prostate tumor cells growing in bone.
Kyle G. Halvorson,Kazufumi Kubota,Molly A. Sevcik,Theodore H. Lindsay,Julio E. Sotillo,Joseph R. Ghilardi,Joseph R. Ghilardi,Thomas J. Rosol,Leila Boustany,David L. Shelton,Patrick W. Mantyh,Patrick W. Mantyh +11 more
TL;DR: The present results suggest that anti-NGF therapy may be effective in reducing pain and enhancing the quality of life in patients with prostate tumor-induced bone cancer pain.
Journal ArticleDOI
Tumor-induced injury of primary afferent sensory nerve fibers in bone cancer pain
Christopher M. Peters,Joseph R. Ghilardi,Cathy P. Keyser,Kazufumi Kubota,Theodore H. Lindsay,Nancy M. Luger,David B. Mach,Matthew J. Schwei,Molly A. Sevcik,Patrick W. Mantyh +9 more
TL;DR: It is suggested that even when the tumor is confined within the bone, a component of bone cancer pain is due to tumor-induced injury to primary afferent nerve fibers that innervate the tumor-bearing bone.