M
Manuel Zimmer
Researcher at Research Institute of Molecular Pathology
Publications - 44
Citations - 4461
Manuel Zimmer is an academic researcher from Research Institute of Molecular Pathology. The author has contributed to research in topics: Caenorhabditis elegans & Premovement neuronal activity. The author has an hindex of 21, co-authored 37 publications receiving 3801 citations. Previous affiliations of Manuel Zimmer include Howard Hughes Medical Institute & Max Planck Society.
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Journal ArticleDOI
Simultaneous whole-animal 3D imaging of neuronal activity using light-field microscopy
Robert Prevedel,Young-Gyu Yoon,Maximilian Hoffmann,Maximilian Hoffmann,Maximilian Hoffmann,Nikita Pak,Gordon Wetzstein,Saul Kato,Tina Schrödel,Ramesh Raskar,Manuel Zimmer,Edward S. Boyden,Alipasha Vaziri,Alipasha Vaziri,Alipasha Vaziri +14 more
TL;DR: This work demonstrates simultaneous functional imaging of neuronal activity at single-neuron resolution in an entire Caenorhabditis elegans and in larval zebrafish brain with high-speed volumetric calcium imaging.
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Microfluidics for in vivo imaging of neuronal and behavioral activity in Caenorhabditis elegans
TL;DR: Two microfluidic chips, the 'behavior' chip and the 'olfactory' chip, are developed for imaging of neuronal and behavioral responses in C. elegans and revealed previously unknown properties of AVA and ASH neurons.
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Global brain dynamics embed the motor command sequence of Caenorhabditis elegans.
Saul Kato,Harris S. Kaplan,Tina Schrödel,Susanne Skora,Theodore H. Lindsay,Eviatar Yemini,Shawn R. Lockery,Manuel Zimmer +7 more
TL;DR: It is shown that the coordination of neuronal activity patterns into global brain dynamics underlies the high-level organization of behavior and serves as a robust scaffold for action selection in response to sensory input.
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EphB-ephrinB bi-directional endocytosis terminates adhesion allowing contact mediated repulsion.
TL;DR: A mechanism for the termination of adhesion and the promotion of cell repulsion after intercellular (trans) interaction between two transmembrane proteins is shown.
Journal ArticleDOI
EphrinB phosphorylation and reverse signaling: regulation by Src kinases and PTP-BL phosphatase.
Amparo Palmer,Manuel Zimmer,Kai S. Erdmann,Volker Eulenburg,Annika Porthin,Rolf Heumann,Urban Deutsch,Rüdiger Klein +7 more
TL;DR: It is shown that Src family kinases (SFKs) are positive regulators of ephrinB phosphorylation and phosphotyrosine-mediated reverse signaling and the presence of a switch mechanism that allows a shift from phosphotYrosine/SFK- dependent signaling to PDZ-dependent signaling is suggested.