Theofilos Poutahidis

TL;DR: It is proposed that the CAF-supported microenvironment has a dual tumor-promoting role, not only does it provide essential signals for cancer cell dedifferentiation, proliferation, and survival but it also facilitates cancer cell local invasion and metastatic phenomena.

TL;DR: The ability of CD4+ T cells to protect against intestinal cancer was correlated with their ability to reduce bacterially induced inflammatory bowel disease, suggesting that regulatory T cells may act directly on the innate immune system to reduce or prevent disease.

TL;DR: Depletion of MC either pharmacologically or through the generation of chimeric mice with genetic lesions in MC development leads to a profound remission of existing polyps, suggesting that MC are an essential hematopoietic component for preneoplastic polyp development and are a novel target for therapeutic intervention.

TL;DR: It is urged that the lifestyle-microbiota-human health nexus be taken into account in societal decision making and within the broader context of terrestrial and aquatic microbial ecosystems that are challenged by the human lifestyle and by agricultural and industrial activities.

TL;DR: Oxytocin is determined to be a novel component of a multi-directional gut microbe-brain-immune axis, with wound-healing capability as a previously unrecognized output of this axis, and experimental evidence is provided to support long-standing medical traditions associating diet, social practices, and the immune system with efficient recovery after injury, sustained good health, and longevity.