M
Michael F. Gurish
Researcher at Brigham and Women's Hospital
Publications - 105
Citations - 10168
Michael F. Gurish is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Mast cell & Proteases. The author has an hindex of 56, co-authored 105 publications receiving 9185 citations. Previous affiliations of Michael F. Gurish include Harvard University & Boston Children's Hospital.
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Journal ArticleDOI
Mast Cells: A Cellular Link Between Autoantibodies and Inflammatory Arthritis
David M. Lee,Daniel S. Friend,Michael F. Gurish,Christophe Benoist,Diane Mathis,Michael B. Brenner +5 more
TL;DR: Two strains of mice deficient in mast cells were resistant to development of joint inflammation and that susceptibility was restored in the W/Wv strain by mast cell engraftment, suggesting mast cells may function as a cellular link between autoantibodies, soluble mediators, and other effector populations in inflammatory arthritis.
Journal ArticleDOI
Pathologically expanded peripheral T helper cell subset drives B cells in rheumatoid arthritis
Deepak A. Rao,Michael F. Gurish,Jennifer L. Marshall,Kamil Slowikowski,Chamith Y. Fonseka,Yanyan Liu,Laura T. Donlin,Lauren A. Henderson,Kevin Wei,Fumitaka Mizoguchi,Nikola Teslovich,Nikola Teslovich,Michael E. Weinblatt,Elena Massarotti,Jonathan S. Coblyn,Simon M. Helfgott,Yvonne C. Lee,Derrick J. Todd,Vivian P. Bykerk,Susan M. Goodman,Susan M. Goodman,Alessandra B. Pernis,Lionel B. Ivashkiv,Elizabeth W. Karlson,Peter A. Nigrovic,Peter A. Nigrovic,Andrew Filer,Christopher D. Buckley,James A. Lederer,Soumya Raychaudhuri,Michael B. Brenner +30 more
TL;DR: Using multidimensional cytometry, transcriptomics, and functional assays, a population of PD-1hiCXCR5− ‘peripheral helper’ T (TPH) cells that express factors enabling B-cell help, including IL-21, CXCL13, ICOS, and MAF are defined.
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Heparin is essential for the storage of specific granule proteases in mast cells
Donald E. Humphries,Guang W. Wong,Daniel S. Friend,Michael F. Gurish,Wen Tao Qiu,Chifu Huang,Arlene H. Sharpe,Richard L. Stevens +7 more
TL;DR: Transgenic mice generated by disrupting the N -deacetylase/N -sulphotransferase-2 gene are described, that cannot express fully sulphated heparin and are shown to controls, through a post-translational mechanism, the levels of specific cassettes of positively charged proteases inside mast cells.
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Developmental checkpoints of the basophil/mast cell lineages in adult murine hematopoiesis
Yojiro Arinobu,Hiromi Iwasaki,Hiromi Iwasaki,Michael F. Gurish,Shinichi Mizuno,Hirokazu Shigematsu,Hidetoshi Ozawa,Daniel G. Tenen,K. Frank Austen,Koichi Akashi +9 more
TL;DR: In this article, the β7 integrin was found to be required for selective homing of mast cell progenitors to the periphery of the mouse spleen, and the granulocyte-related transcription factor CCAAT/enhancer-binding protein α (C/EBPα) played a primary role in the fate decision of BMCPs, being expressed in BaPs but not in MCPs.
Journal ArticleDOI
Cooperative and antagonistic interplay between PU.1 and GATA-2 in the specification of myeloid cell fates.
Jonathan C Walsh,Rodney P. DeKoter,Hyun Jun Lee,Erica D. Smith,David W. Lancki,Michael F. Gurish,Daniel S. Friend,Richard L. Stevens,John Anastasi,Harinder Singh,Harinder Singh +10 more
TL;DR: A developmental model in which cooperative function or antagonistic crossregulation by PU.1 and GATA transcription factors appear to antagonize each other's function in the development of distinct lineages of the hematopoietic system is proposed.