Thérèse Traoré-Leroux

TL;DR: Analyzing the isotypic distribution of the IgG response to conserved epitopes and P. falciparum blood-stage extract in 283 malaria-exposed individuals favors a protective role of IgG3 and IgG2, which may activate effector cells through FcγRIIA, and provides evidence for a blocking role for IgG4 in malarial infection and disease.

TL;DR: Sib-pair linkage analyses between blood infection levels and chromosome 5q31-q33, which contains numerous candidate genes encoding immunological molecules indicate that the locus plays a central role in the control of parasitemia, and the identification of the gene is of major interest in understanding the mechanisms controlling P. falciparum Parasitemia.

TL;DR: There was a strong interaction between major effect and age, suggesting that the influence of the putative major gene may be more prominent in children than in adults, and it was found that blood parasite densities were correlated between sibs.

TL;DR: A segregation analysis based on blood parasite load phenotype for a population of the town of Bobo-Dioulasso (Burkina-Faso), which demonstrated a strong genetic effect, suggests that parasite load is under the control of minor genes.

TL;DR: This paper focuses on segregation and linkage analyses of blood infection levels in an urban population living in Burkina Faso and finds evidence of a complex genetic control and a linkage to chromosome 5q31-q33.