Francis Fumoux

TL;DR: Analyzing the isotypic distribution of the IgG response to conserved epitopes and P. falciparum blood-stage extract in 283 malaria-exposed individuals favors a protective role of IgG3 and IgG2, which may activate effector cells through FcγRIIA, and provides evidence for a blocking role for IgG4 in malarial infection and disease.

TL;DR: Sib-pair linkage analyses between blood infection levels and chromosome 5q31-q33, which contains numerous candidate genes encoding immunological molecules indicate that the locus plays a central role in the control of parasitemia, and the identification of the gene is of major interest in understanding the mechanisms controlling P. falciparum Parasitemia.

TL;DR: High genetic diversity in hepatitis C virus (HCV) and its genotypes implies that HCV infection is long‐established in these West African regions and poses a challenge for vaccine development.

TL;DR: Using a large sampling of EBV clones, it is found that the pattern of VH and VK family usage was similar, and the level of light chain expression (K + lambda) was about two-fold that of heavy chains, suggesting that the Vh and the VK repertoires are not regulated by a similar selective process.

TL;DR: In this article, a longitudinal study of families living in an endemic area, investigated whether hemoglobin C is associated with reduced Plasmodium falciparum parasitemia and low risk of mild malaria attack.