T
Thibaud Dieudonné
Researcher at Université Paris-Saclay
Publications - 15
Citations - 250
Thibaud Dieudonné is an academic researcher from Université Paris-Saclay. The author has contributed to research in topics: Flippase & Chemistry. The author has an hindex of 6, co-authored 10 publications receiving 133 citations. Previous affiliations of Thibaud Dieudonné include Aarhus University.
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Journal ArticleDOI
Structure and autoregulation of a P4-ATPase lipid flippase
Milena Timcenko,Joseph A. Lyons,Dovile Januliene,Jakob Ulstrup,Thibaud Dieudonné,Cédric Montigny,Miriam-Rose Ash,Jesper Lykkegaard Karlsen,Thomas Boesen,Werner Kühlbrandt,Guillaume Lenoir,Arne Moeller,Poul Nissen +12 more
TL;DR: Cryo-EM structures of the yeast P4-ATPase Drs2p–Cdc50p in three different states of activation provide insights into the function of this lipid flippase, including mechanisms of autoinhibition and PI4P-dependent activation.
Journal ArticleDOI
High phosphatidylinositol 4-phosphate (PI4P)-dependent ATPase activity for the Drs2p-Cdc50p flippase after removal of its N- and C-terminal extensions.
Hassina Azouaoui,Cédric Montigny,Thibaud Dieudonné,Philippe Champeil,Aurore Jacquot,José Luis Vázquez-Ibar,Pierre Le Maréchal,Jakob Ulstrup,Miriam-Rose Ash,Joseph A. Lyons,Poul Nissen,Guillaume Lenoir +11 more
TL;DR: It is revealed that trimming off appropriate regions of the terminal extensions of Drs2p can greatly increase its ATPase activity in the presence of PI4P and demonstrate that relief of such auto-inhibition remains compatible with subsequent regulation byPI4P.
Journal ArticleDOI
Structural Basis of Substrate-Independent Phosphorylation in a P4-ATPase Lipid Flippase
Milena Timcenko,Thibaud Dieudonné,Cédric Montigny,Thomas Boesen,Joseph A. Lyons,Guillaume Lenoir,Poul Nissen +6 more
TL;DR: In this paper, the structural basis of the distinct mechanisms of P4-ATPases is studied. But the authors focus on the dephosphorylation half-reaction, which is not associated with transport.
Journal ArticleDOI
P4-ATPases: how an old dog learnt new tricks - structure and mechanism of lipid flippases.
TL;DR: The recent lipid flippase structures in the context of subunit architecture and organization, auto-regulation and lipid transport are discussed, highlighting the similarities and differences they share with the cation transporting P-type ATPases.
Journal ArticleDOI
ATP2, The essential P4-ATPase of malaria parasites, catalyzes lipid-stimulated ATP hydrolysis in complex with a Cdc50 β-subunit.
Anaïs Lamy,Anaïs Lamy,Ewerton Macarini-Bruzaferro,Ewerton Macarini-Bruzaferro,Thibaud Dieudonné,Thibaud Dieudonné,Alex Perálvarez-Marín,Guillaume Lenoir,Cédric Montigny,Marc le Maire,José Luis Vázquez-Ibar +10 more
TL;DR: In this paper, gene targeting approaches have demonstrated the essential role for the malaria parasite of membrane transport proteins involved in lipid transport and in the maintenance of membrane lipid asymmetry, and the importance of the transport proteins in the malaria infection.